Document Detail

KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential.
MedLine Citation:
PMID:  16053918     Owner:  NLM     Status:  MEDLINE    
We identified a 1A6/DRIM (down-regulated in metastasis) interacting protein, KIAA0649 during the yeast two-hybrid screen. The interaction between KIAA0649 and 1A6/DRIM was further confirmed by GST-pull-down and co-immunoprecipitation assays. KIAA0649 was originally identified from human brain tissue. However, its biological function remains unknown. In this report, we showed that KIAA0649 mRNA is widely expressed in human multiple tissues and cell lines. We have also demonstrated that KIAA0649 has oncogenic characteristics: it enhances colony formation, allows anchorage-independent growth. Moreover, KIAA0649 exogenous expression in NIH3T3 fibroblasts caused tumor development in nude mice.
Lin Yang; Jun Zhao; Wenqing Lü; Yong Li; Xiaojuan Du; Tao Ning; Guirong Lu; Yang Ke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  334     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-01     Completed Date:  2006-07-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  884-90     Citation Subset:  IM    
Beijing Institute for Cancer Research, School of Oncology, Peking University No. 1 Da Hong Luo Chang St, West District, Beijing 100034, PR China.
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MeSH Terms
COS Cells
Cell Line, Tumor
Cell Proliferation / drug effects
Cell Transformation, Neoplastic
Cercopithecus aethiops
Hela Cells
Mice, Nude
NIH 3T3 Cells
Nerve Tissue Proteins / metabolism*
Nuclear Proteins
Oncogene Proteins / metabolism*
Proteins / metabolism*
Two-Hybrid System Techniques
Reg. No./Substance:
0/KIAA0649 protein, human; 0/Nerve Tissue Proteins; 0/Nuclear Proteins; 0/Oncogene Proteins; 0/Proteins; 0/Ribonucleoproteins; 0/UTP20 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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