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The KCNJ11 E23K gene polymorphism and type 2 diabetes mellitus in the Chinese Han population: a meta-analysis of 6,109 subjects.
MedLine Citation:
PMID:  23054005     Owner:  NLM     Status:  Publisher    
Potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) E23K gene polymorphism has been indicated as relevant to type 2 diabetes mellitus (T2D) susceptibility, but research results remain debatable.To investigate the relationship between KCNJ11 E23K gene polymorphism and T2D in the Chinese Han population, a meta-analysis involving 3,080 T2D patients and 3,029 controls from five separate studies was conducted. The pooled odds ratio (ORs) for the association between KCNJ11 E23K gene polymorphism and T2D and its corresponding 95 % confidence interval (95 % CI) were estimated using a random effects model.A significant association was observed between the KCNJ11 E23K gene polymorphism and T2D in the pooled Chinese Han population through an allelic genetic model (OR: 1.21, 95 % CI: 1.04-1.40, P = 0.01) and a recessive genetic model (OR: 1.44, 95 % CI: 1.25-1.65, P < 0.00001). In contrast, no significant association was observed between the KCNJ11 E23K gene polymorphism and T2D in the dominant genetic model (OR: 0.66, 95 % CI: 0.41-1.07, P = 0.09).The KCNJ11 E23K gene polymorphism is associated with T2D risk in the Chinese Han population.
Yan-Yan Li
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  Molecular biology reports     Volume:  -     ISSN:  1573-4978     ISO Abbreviation:  Mol. Biol. Rep.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China,
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