Document Detail


KCNE gene expression is dependent on the proliferation and mode of activation of leukocytes.
MedLine Citation:
PMID:  23327879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Voltage-dependent K (+) (Kv) channels are tightly regulated during the immune system response. Leukocytes have a limited repertoire of Kv channels, whose physiological role is under intense investigation. A functional Kv channel is an oligomeric complex composed of pore-forming and ancillary subunits. The KCNE gene family is a novel group of modulatory Kv channel elements in leukocytes. Here, we characterized the gene expression of KCNEs (1-5) in leukocytes and investigated their regulation during leukocyte proliferation and mode of activation. Murine bone-marrow-derived macrophages, human Jurkat T-lymphocytes and human Raji B-cells were analyzed. KCNEs (1-5) are expressed in all leukocytes lineages. Most KCNE mRNAs show cell cycle-dependent regulation and are differentially regulated under specific insults. Our results further suggest a new and yet undefined physiological role for KCNE subunits in the immune system. Putative associations of these ancillary proteins with Kv channels would yield a wide variety of biophysically and pharmacologically distinct channels that fine-tune the immunological response.
Authors:
Laura Solé; Albert Vallejo-Gracia; Sara R Roig; Antonio Serrano-Albarrás; Laura Marruecos; Joan Manils; Diana Gómez; Concepció Soler; Antonio Felipe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-17
Journal Detail:
Title:  Channels (Austin, Tex.)     Volume:  7     ISSN:  1933-6969     ISO Abbreviation:  Channels (Austin)     Publication Date:    2013 Mar-Apr
Date Detail:
Created Date:  2013-05-13     Completed Date:  2013-11-22     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  101321614     Medline TA:  Channels (Austin)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-96     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Proliferation*
Humans
Leukocytes / immunology,  metabolism*,  physiology
Lymphocyte Activation*
Macrophages / metabolism,  physiology
Mice
Potassium Channels, Voltage-Gated / genetics,  immunology,  metabolism*
Protein Subunits / genetics,  immunology,  metabolism
Transcription, Genetic
Chemical
Reg. No./Substance:
0/Potassium Channels, Voltage-Gated; 0/Protein Subunits
Comments/Corrections

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