| KCNE gene expression is dependent on the proliferation and mode of activation of leukocytes. | |
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MedLine Citation:
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PMID: 23327879 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Voltage-dependent K (+) (Kv) channels are tightly regulated during the immune system response. Leukocytes have a limited repertoire of Kv channels, whose physiological role is under intense investigation. A functional Kv channel is an oligomeric complex composed of pore-forming and ancillary subunits. The KCNE gene family is a novel group of modulatory Kv channel elements in leukocytes. Here, we characterized the gene expression of KCNEs (1-5) in leukocytes and investigated their regulation during leukocyte proliferation and mode of activation. Murine bone-marrow-derived macrophages, human Jurkat T-lymphocytes and human Raji B-cells were analyzed. KCNEs (1-5) are expressed in all leukocytes lineages. Most KCNE mRNAs show cell cycle-dependent regulation and are differentially regulated under specific insults. Our results further suggest a new and yet undefined physiological role for KCNE subunits in the immune system. Putative associations of these ancillary proteins with Kv channels would yield a wide variety of biophysically and pharmacologically distinct channels that fine-tune the immunological response. |
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Authors:
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Laura Solé; Albert Vallejo-Gracia; Sara R Roig; Antonio Serrano-Albarrás; Laura Marruecos; Joan Manils; Diana Gómez; Concepció Soler; Antonio Felipe |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-17 |
Journal Detail:
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Title: Channels (Austin, Tex.) Volume: 7 ISSN: 1933-6969 ISO Abbreviation: Channels (Austin) Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101321614 Medline TA: Channels (Austin) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Molecular Physiology Laboratory; Departament de Bioquímica i Biologia Molecular; Institut de Biomedicina; Universitat de Barcelona; Barcelona, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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