| K(ATP) channels and pancreatic islet blood flow in anesthetized rats: increased blood flow induced by potassium channel openers. | |
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MedLine Citation:
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PMID: 12882921 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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K(ATP) channels are important for insulin secretion and depolarization of vascular smooth muscle. In view of the importance of drugs affecting K(ATP) channels in the treatment of diabetes, we investigated the effects of these channels on splanchnic blood perfusion in general and pancreatic islet blood flow in particular. We treated anesthetized Sprague-Dawley rats with the K(ATP) channel openers diazoxide or NNC 55-0118 or the K(ATP) channel closer glipizide. Both diazoxide and NNC 55-0118 dose-dependently increased total pancreatic and islet blood flow in the presence of moderate hyperglycemia, but had no effects on the blood perfusion of other splanchnic organs. Diazoxide markedly lowered the mean arterial blood pressure and thus increased vascular conductance in all organs studied. NNC 55-0118 had much smaller effects on the blood pressure. Glipizide did not affect total pancreatic blood flow, but decreased islet blood flow by 50% in the presence of hypoglycemia. We conclude that K(ATP) channels actively participate in the blood flow regulation of the pancreatic islets and that substances affecting such channels may also influence islet blood flow. |
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Authors:
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Leif Jansson; Mikael Kullin; F Anders Karlsson; Birgitta Bodin; John Bondo Hansen; Stellan Sandler |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetes Volume: 52 ISSN: 0012-1797 ISO Abbreviation: Diabetes Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-28 Completed Date: 2003-09-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: United States |
Other Details:
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Languages: eng Pagination: 2043-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden. leif.jansson@medcellbiol.uu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Anesthesia Animals Diazoxide / analogs & derivatives*, pharmacology Glipizide / pharmacology Hypoglycemic Agents / pharmacology Islets of Langerhans / blood supply*, metabolism* Male Muscle, Smooth, Vascular / metabolism* Potassium Channels / agonists, metabolism* Rats Rats, Sprague-Dawley Regional Blood Flow / drug effects, physiology Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 0/NNC 55-0118; 0/Potassium Channels; 0/Vasodilator Agents; 29094-61-9/Glipizide; 364-98-7/Diazoxide; 56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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