| K(ATP) channel activation reduces the severity of postresuscitation myocardial dysfunction. | |
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MedLine Citation:
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PMID: 11009447 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postresuscitation myocardial dysfunction has been recognized as a leading cause of the high postresuscitation mortality rate. We investigated the effects of ischemic preconditioning and activation of ATP-sensitive K(+) (K(ATP)) channels on postresuscitation myocardial function. Ventricular fibrillation (VF) was induced in 25 Sprague-Dawley rats. Cardiopulmonary resuscitation (CPR), including mechanical ventilation and precordial compression, was initiated after 4 min of untreated VF. Defibrillation was attempted after 6 min of CPR. The animals were randomized to five groups treated with 1) ischemic preconditioning, 2) K(ATP) channel opener, 3) ischemic preconditioning with K(ATP) channel blocker administered 1 min after VF, 4) K(ATP) channel blocker administered 45 min before induction of ischemic preconditioning, and 5) placebo. Postresuscitation myocardial function, as measured by the rate of left ventricular pressure increase at 40 mmHg, the rate of left ventricular decline, cardiac index, and duration of survival, was significantly improved in both preconditioned and K(ATP) channel opener-treated animals. K(ATP) channel blocker administered 45 min before induction of ischemic preconditioning completely abolished the myocardial protective effects of preconditioning. We conclude that ischemic preconditioning significantly improved post-CPR myocardial function and survival. These results also provide evidence that the myocardial protective effects of ischemic preconditioning are mediated by K(ATP) channel activation. |
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Authors:
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W Tang; M H Weil; S Sun; A Pernat; E Mason |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 279 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-10-23 Completed Date: 2000-11-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H1609-15 Citation Subset: IM |
Affiliation:
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Institute of Critical Care Medicine, Palm Springs 92262, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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physiology* Animals Antihypertensive Agents / therapeutic use Blood Pressure / drug effects Cardiac Complexes, Premature / epidemiology Coronary Circulation Cromakalim / therapeutic use Glyburide / therapeutic use Heart / physiopathology* Incidence Ischemic Preconditioning, Myocardial Perfusion Potassium Channels / physiology* Rats Rats, Sprague-Dawley Resuscitation* Survival Analysis |
| Grant Support | |
ID/Acronym/Agency:
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HL-54322/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Potassium Channels; 10238-21-8/Glyburide; 56-65-5/Adenosine Triphosphate; 94470-67-4/Cromakalim |
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