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KAI1 gene is differently expressed in papillary and pancreatic cancer: influence on metastasis.
MedLine Citation:
PMID:  11819710     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM:To compare KAI1 in cancer of papilla of Vater and pancreas to evaluate whether there are differences in biologic behavior which might account for prognosis.METHODS:We compared the expression in 24 papillay and 29 pancreatic cancers using Northern blot analysis, immunochemical assay and in situ hybridization, and investigated whether early diagnosis or molecular differences predict the outcome in these tumor entities.RESULTS:By Northern blot analysis there is no statistical difference of KAI1 levels in normal and cancerous papilla. No association between KAI1 mRNA expression and tumor stage or tumor differentiation was found in the tumors. By immunohistochemical assay, KAI1 staining in cytoplasm of papillary cancer cells was similar to that of normal papillary cells. By in situ hybridization, the results of KAI1 mRNA expression in normal and cancerous papilla were similar to those with immunohistochemical assay. The normal and cancerous pancreas tissues were also analyzed by the methods used in papillary samples.CONCLUSION:Although the biologic roles of KAI1 have not been clarified, our results suggest that KAI1 may restrict the progression of malignant papillary cancer, but its expression might not have any effect on the characteristics of papillary tumor, whereas by the analysis of KAI1 gene, its reduced expression is closely related to the progression and metastases of pancreatic cancer.
Authors:
Xiao-Zhong Guo; Helmut Friess; Xiao-Dong Shao; Min-Pei Liu; Yu-Ting Xia; Jian-Hua Xu; Markus W Buchler
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  6     ISSN:  -     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2002-Jan-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  866-871     Citation Subset:  -    
Affiliation:
Department of Gastroenterology, Shenyang General Hospital, Shenyang 110015, Liaoning Province,China. guo xzsw@pub.sy.ln.cn
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