Document Detail


K16 expression in uninvolved psoriatic skin: a possible marker of pre-clinical psoriasis.
MedLine Citation:
PMID:  15239676     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: K16, a type I keratin, is upregulated in hyperproliferative states including psoriasis. It has been used as a marker of psoriasis and its expression is upregulated in relapsing psoriasis and downregulating in resolving. We evaluated non-lesional psoriatic skin for K16 expression. METHODS: Sixty-seven non-lesional and lesional skin samples from patients with psoriasis and normal skin from 19 non-psoriatic patients were studied by immunohistochemistry on frozen sections with K16. RESULTS: Seventeen of 19 normal skin samples showed staining of basal cells in the deeper part of the rete ridges. Sixty-two non-lesional psoriatic skin samples showed intense basal staining of K16. Of the remaining five non-lesional samples, diffuse intense suprabasal staining in one, pan-epidermal staining in two, and no staining was seen in two samples. Suprabasal (37), diffuse (14), sandwich (12), and basal (3) pattern staining were seen in psoriatic skin. One psoriatic skin sample did not show any expression. CONCLUSION: Our results demonstrate that K16 expression is also observed in non-lesional psoriatic skin and may serve as a marker of preclinical psoriasis.
Authors:
Jag Bhawan; Cheryl Bansal; Kara Whren; Ullrich Schwertschlag;
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  31     ISSN:  0303-6987     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-08     Completed Date:  2005-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  471-6     Citation Subset:  IM    
Affiliation:
Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA. jbhawan@bu.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Biological Markers / analysis*
Female
Humans
Immunohistochemistry
Keratin-1
Keratins / biosynthesis*
Male
Middle Aged
Psoriasis / metabolism*
Skin / metabolism*,  pathology*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/KRT1 protein, human; 0/Keratin-1; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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