| K+ channel blockade in the prevention of ventricular fibrillation in dogs with acute ischemia and enhanced sympathetic activity. | |
| | |
MedLine Citation:
|
PMID: 8606519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The value of K+ channel blockade in preventing lethal arrhythmias, and specifically those triggered by acute myocardial ischemia and sympathetic hyperactivity, remains unproven. To address this issue, we tested the antifibrillatory effect of d-sotalol, and Ikr blocker, d,l-sotalol, its racemic compound which blocks Ikr, and beta-adrenoreceptors, and propranolol. Ten dogs with a healed anterior myocardial infarction (MI) had ventricular fibrillation (VF) during a 2-min occlusion of the circumflex coronary artery performed toward the end of a submaximal exercise stress test. In successive trials in the same animals, d-sotalol (three injections of 8 mg/kg, one every 12 h), d,l-sotalol (8 mg/kg), and propranolol (1 mg/kg) were tested. All three interventions significantly reduced heart rate (HR) response to exercise, but only d,l-sotalol and propranolol also blunted the reflex HR increase during acute myocardial ischemia. With d-sotalol, HR at 30 s of coronary occlusion was similar (253 +/- 28 beats/min) to that observed in the control tests (259 +/- 35 beats/min). d-Sotalol prevented recurrence of VF in only 1 of 10 dogs tested. One dog was lost to the continuation of the study after occurrence of VF with d-sotalol. Six of 9 dogs (67%) tested with d,l-sotalol and 5 (56%) of the same 9 dogs tested with propranolol were protected from VF. d-Sotalol does not reduce risk of VF during acute myocardial ischemia associated with sympathetic hyperactivity, and lethal events can be prevented by antiadrenergic interventions. |
| | |
Authors:
|
E Vanoli; S S Hull; P B Adamson; R D Foreman; P J Schwartz |
Related Documents
:
|
15227259 - Prevention of ventricular fibrillation after aortic declamping during cardiac surgery. 679429 - Actions of lidocaine on transmembrane potentials of subendocardial purkinje fibers surv... 9704679 - Intravenous adenosine and lidocaine in patients with acute myocardial infarction. 633069 - Antiarrhythmic, metabolic and hemodynamic effects of org 6001 (3alpha-amino-5alpha-andr... 7065489 - Les torsades des pointes. 1130269 - Effect of autonomic neural influences on the cardiovascular changes induced by coronary... 1607539 - Coexistence of mitral valve prolapse in a consecutive group of 528 patients with hypert... 11509449 - Action potential characteristics and arrhythmogenic properties of the cardiac conductio... 16996849 - St-segment abnormalities and premature complexes are predictors of new-onset atrial fib... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of cardiovascular pharmacology Volume: 26 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1995 Dec |
Date Detail:
|
Created Date: 1996-05-23 Completed Date: 1996-05-23 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 847-54 Citation Subset: IM |
Affiliation:
|
Istituto di Clinica Medica Generale e Terapia Medica, Università di Milano, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anti-Arrhythmia Agents / pharmacology* Blood Pressure / drug effects Dogs Electrocardiography Heart Rate / drug effects Myocardial Ischemia / complications*, physiopathology Potassium Channel Blockers* Propranolol / pharmacology Sotalol / pharmacology* Stereoisomerism Sympathetic Nervous System / drug effects*, physiopathology Ventricular Fibrillation / prevention & control* |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Arrhythmia Agents; 0/Potassium Channel Blockers; 3930-20-9/Sotalol; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fresh vein allograft survival in dogs after cyclosporine treatment.
Next Document: Myocardial depression by isoflurane is dependent on the underlying beta-adrenergic tone.