Document Detail

Juvenile xanthogranuloma developing after treatment of Langerhans cell histiocytosis: case report and literature review.
MedLine Citation:
PMID:  22977671     Owner:  NLM     Status:  MEDLINE    
The synchronous or metachronous development of Langerhans cell histiocytosis and non-Langerhans cell histiocytosis in the same patient is rare. To date, only seven cases of xanthogranulomas developing in young patients with a history of Langerhans cell histiocytosis and systemic therapy have been reported in the literature. As of yet, the pathogenesis and the clinical significance of this phenomenon are unclear. We report the case of a 3 year old boy who developed juvenile Xanthogranulomas on the forehead and right upper eye lid 1.5 years after systemic therapy for monosystemic Langerhans cell histiocytosis of the bone and complete disease remission.
Johanna D Strehl; Klaus-Daniel Stachel; Arndt Hartmann; Abbas Agaimy
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2012-09-05
Journal Detail:
Title:  International journal of clinical and experimental pathology     Volume:  5     ISSN:  1936-2625     ISO Abbreviation:  Int J Clin Exp Pathol     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-14     Completed Date:  2013-02-07     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101480565     Medline TA:  Int J Clin Exp Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  720-5     Citation Subset:  IM    
Institute of Pathology, Erlangen, Germany.
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MeSH Terms
Antineoplastic Agents, Phytogenic / therapeutic use
Child, Preschool
Eyelid Diseases / etiology*,  pathology,  surgery
Glucocorticoids / therapeutic use
Histiocytosis, Langerhans-Cell / drug therapy*
Prednisone / therapeutic use
Treatment Outcome
Vinblastine / therapeutic use
Xanthogranuloma, Juvenile / etiology*,  pathology,  surgery
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Glucocorticoids; 53-03-2/Prednisone; 865-21-4/Vinblastine

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