| Juvenile rats show reduced c-fos activity in neural sites associated with aversion to pups and inhibition of maternal behavior. | |
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MedLine Citation:
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PMID: 16187837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Juvenile rats (18-23 days old) interact avidly with pups as novel stimuli and show maternal behavior after only 1-3 days of pup exposure; adults initially avoid pups and require 3-9 days of pup exposure. Upon exposure to pups as novel stimuli, adults had more c-Fos-immunoreactive neurons in the hypothalamus and amygdala--regions associated with aversion to pups--than adults exposed to familiar pup stimuli (maternal) or not exposed to pups (p < .05). In juvenile rats exposed to pups as novel stimuli, only the medial amygdala had a small significant increase of c-Fos neurons. In juveniles, this blunted engagement of c-Fos neurons may reflect the diminished activation of inhibitory neurons, facilitating the interaction of juveniles with pups as novel stimuli and onset of maternal behavior. |
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Authors:
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D E Olazábal; J I Morrell |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Behavioral neuroscience Volume: 119 ISSN: 0735-7044 ISO Abbreviation: Behav. Neurosci. Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-09-28 Completed Date: 2006-01-23 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8302411 Medline TA: Behav Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 1097-110 Citation Subset: IM |
Copyright Information:
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(c) 2005 APA |
Affiliation:
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Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Camden, NJ, US. dolazab@emory.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Amygdala / cytology* Animals Animals, Newborn Behavior, Animal Cell Count / methods Female Gene Expression Regulation, Developmental / physiology* Hypothalamus / cytology* Immunohistochemistry / methods Lactation / physiology Male Maternal Behavior / physiology* Neurons / metabolism* Nucleus Accumbens / cytology Pregnancy Proto-Oncogene Proteins c-fos / metabolism* Rats |
| Grant Support | |
ID/Acronym/Agency:
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R01 DA014025-02/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins c-fos |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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