Document Detail

Juvenile rats in the forced-swim test model the human response to antidepressant treatment for pediatric depression.
MedLine Citation:
PMID:  18180907     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Currently, there are limited treatment options for major depressive disorder in children and adolescents compared to the options available for adults. Many effective treatments used for adult depression, such as the tricyclic antidepressants, lack efficacy when given to children and adolescents. OBJECTIVE: To more quickly identify compounds that could be effective for treating childhood and adolescent depression, a reliable preclinical animal behavioral test of antidepressant efficacy for pediatric depression is needed. The forced-swim test (FST) with juvenile rats was assessed to determine its reliability as a predictive model for pediatric depression. MATERIALS AND METHODS: We adapted procedures from the adult FST to test 21-day-old juvenile rats. The 21-day-old animals were treated with three classes of antidepressant drugs before being assessed in the FST: the selective serotonin reuptake inhibitors escitalopram or fluoxetine; the tricyclic antidepressants desipramine or imipramine; and the monoamine oxidase inhibitor tranylcypromine. RESULTS: The 21-day-old rats showed dose-dependent changes in behaviors similar to those seen in adults when treated with escitalopram or fluoxetine. Tranylcypromine also decreased immobility in 21-day-old rats. Treatment with desipramine or imipramine, however, was not effective at reducing immobility in the 21-day-old rats. CONCLUSIONS: The juvenile FST accurately predicts the efficacy of selective serotonin reuptake inhibitors and the lack of efficacy of tricyclic antidepressants in the treatment of depression in children and adolescents. This suggests that the FST using 21-day-old rats may help to develop better treatments for childhood and adolescent depression.
Abbey L Reed; H Kevin Happe; Frederick Petty; David B Bylund
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-01-08
Journal Detail:
Title:  Psychopharmacology     Volume:  197     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-21     Completed Date:  2008-08-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  433-41     Citation Subset:  IM    
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.
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MeSH Terms
Age Factors
Antidepressive Agents / therapeutic use*
Citalopram / therapeutic use
Depressive Disorder / drug therapy*,  psychology
Desipramine / therapeutic use
Disease Models, Animal*
Escape Reaction / drug effects
Fluoxetine / therapeutic use
Helplessness, Learned*
Imipramine / therapeutic use
Injections, Intraperitoneal
Rats, Sprague-Dawley
Tranylcypromine / therapeutic use
Grant Support
Reg. No./Substance:
0/Antidepressive Agents; 155-09-9/Tranylcypromine; 50-47-5/Desipramine; 50-49-7/Imipramine; 54910-89-3/Fluoxetine; 59729-33-8/Citalopram

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