Document Detail


Juvenile onset Systemic Lupus Erythematosus thyroid dysfunction: a subgroup with mild disease?
MedLine Citation:
PMID:  19419839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to evaluate the frequency of thyroid dysfunction and thyroid antibodies in patients with juvenile onset Systemic Lupus Erythematosus (JOSLE) and its association with clinical and immunological features. Seventy-seven patients with JOSLE, 64 females, median age 19 years, were consecutively enrolled from March to December 2007. Clinical data related to thyroid dysfunction and lupus were obtained by chart review and patient interview. Serum levels of TSH, free T4, anti-thyroglobulin (TgAb), anti-thyroperoxidase (TPOAb), TRAb and lupus related autoantibodies were analyzed by standard techniques. Nine patients were diagnosed as hypothyroidism and 4 hyperthyroidism. 28% JOSLE patients had moderate/high titer of thyroid antibodies: 23% TgAb, 2.6% TPOAb and 3.9% TRAb. JOSLE patients with positive thyroid autoantibodies had higher frequency of anti-U1RNP antibodies than patients without these antibodies (40.9 vs. 14.5%, OR:0.25, CI:0.08-0.76, p = 0.017). Furthermore, renal/neurological/hematological involvement was less frequently observed in patients with hypothyroidism (55.6 vs. 87.5%, OR:0.18, CI:0.04-0.81, p = 0.035) and with thyroid antibodies (68.4 vs. 90.9%, OR:0.22, CI:0.06-0.82, p = 0.027) than in patients without these alterations. No association with PTPN22 polymorphism was found. In conclusion, JOSLE patients have high prevalence of subclinical hypothyroidism. The novel association of anti-thyroid antibodies with anti-U1RNP antibodies in JOSLE seems to identify a subgroup of patients with less life-threatening organ involvement.
Authors:
Luciana Parente Costa; Eloisa Bonfá; Ciro D Martinago; Ricardo M de Oliveira; Jozélio Freire Carvalho; Rosa M R Pereira
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Publication Detail:
Type:  Journal Article     Date:  2009-05-05
Journal Detail:
Title:  Journal of autoimmunity     Volume:  33     ISSN:  1095-9157     ISO Abbreviation:  J. Autoimmun.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-14     Completed Date:  2009-10-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8812164     Medline TA:  J Autoimmun     Country:  England    
Other Details:
Languages:  eng     Pagination:  121-4     Citation Subset:  IM    
Affiliation:
Rheumatology Division, e Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil. lucianapc@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Autoantibodies / blood*
Autoantigens / immunology
Child
Female
Genotype
Humans
Iodide Peroxidase / immunology
Iron-Binding Proteins / immunology
Lupus Erythematosus, Systemic / complications*,  genetics
Male
Polymorphism, Single Nucleotide / genetics
Protein Tyrosine Phosphatase, Non-Receptor Type 22 / genetics,  immunology,  metabolism
Receptors, Thyrotropin / immunology
Ribonucleoprotein, U1 Small Nuclear / blood
Thyroid Diseases / genetics,  immunology*
Thyrotropin / blood
Thyroxine / blood
Young Adult
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Autoantigens; 0/Iron-Binding Proteins; 0/Receptors, Thyrotropin; 0/Ribonucleoprotein, U1 Small Nuclear; 0/anti-thyroglobulin; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin; EC 1.11.1.7/TPO protein, human; EC 1.11.1.8/Iodide Peroxidase; EC 3.1.3.48/PTPN22 protein, human; EC 3.1.3.48/Protein Tyrosine Phosphatase, Non-Receptor Type 22

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