Document Detail

Juvenile myasthenia gravis: three case reports and a literature review.
MedLine Citation:
PMID:  19406758     Owner:  NLM     Status:  MEDLINE    
Juvenile myasthenia gravis is a rare disorder acquired in childhood, representing 10% to 15% of all cases of myasthenia gravis. Like the adult form, it is generally characterized by an autoimmune attack on acetylcholine receptors at the neuromuscular junction. Most patients present with ptosis, diplopia, and fatigability. More advanced cases may also have bulbar problems and limb weakness. Left untreated, the disease may progress to paralysis of the respiratory muscles. Early recognition of this disease helps avoid unnecessary testing, prevent undue parental anxiety, and stop the progression of symptoms. Here, we relate the clinical course and current status of 3 patients with juvenile myasthenia gravis, discuss the disease in general, and review current treatment modalities.
Paul Gadient; Jeffrey Bolton; Vinay Puri
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of child neurology     Volume:  24     ISSN:  1708-8283     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-01     Completed Date:  2009-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  584-90     Citation Subset:  IM    
Departments of Neurology and Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky, USA.
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MeSH Terms
Blepharoptosis / etiology
Child, Preschool
Clinical Trials as Topic
Diagnosis, Differential
Diplopia / etiology
Fatigue / etiology
Myasthenia Gravis / diagnosis,  physiopathology*,  therapy*
Neuromuscular Diseases / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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