| Juvenile hormone stimulated tyrosine kinase-mediated protein phosphorylation in the CNS of the silk worm, Bombyx mori. | |
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MedLine Citation:
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PMID: 12111974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In vitro studies with the larval CNS of the silkworm, Bombyx mori revealed the phosphorylation of a 48-kDa protein, which was not dependent on cyclic nucleotides. Studies also revealed modest phosphorylation of this protein by a calcium-dependent but calmodulin-independent mechanism. However, phosphorylation of this protein was greatly enhanced in the presence of juvenile hormone (JH) I by a calcium-independent mechanism. This stimulatory effect of JH was seen in both homogenates as well as in intact CNS of Bombyx. Immunoblotting studies revealed the cross-reaction of this 48-kDa protein with phosphotyrosine monoclonal antibody and the phosphorylation of this protein was inhibited by genistein. This study suggests that the 48-kDa protein is a substrate for tyrosine kinase. The phosphorylation of this protein was also observed in other larval tissues such as salivary gland, fat body, and epidermis of Bombyx. |
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Authors:
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A Arif; A Shanavas; Ch R K Murthy; Aparna Dutta-Gupta |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of insect biochemistry and physiology Volume: 50 ISSN: 0739-4462 ISO Abbreviation: Arch. Insect Biochem. Physiol. Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-07-11 Completed Date: 2002-08-22 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8501752 Medline TA: Arch Insect Biochem Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 139-46 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Wiley-Liss, Inc. |
Affiliation:
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Department of Animal Sciences, School of Life Sciences, University of Hyderabad, Hyderabad, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bombyx / metabolism Central Nervous System / metabolism* Insect Proteins / metabolism* Juvenile Hormones / metabolism* Phosphorylation Protein-Tyrosine Kinases / metabolism* Sesquiterpenes / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Insect Proteins; 0/Juvenile Hormones; 0/Sesquiterpenes; 23314-84-3/juvenile hormone I; EC 2.7.10.1/Protein-Tyrosine Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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