| Just taller or more bone? The impact of growth hormone on osteogenesis imperfecta and idiopathic juvenile osteoporosis. | |
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MedLine Citation:
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PMID: 11086654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There are scant data to date on the use of GH therapy in osteogenesis imperfecta (OI) or in idiopathic juvenile osteoporosis (IJO). In OI, we review three clinical trials (aggregate study population 46), and 13 patient reports from the NCGS, and two independent patient reports. Based on evidence of increased growth rate versus some reported increased fracture rate, we conclude that GH should probably not be used as first-line therapy in OI, pending further data from clinical trials. There are no published reports of the use of GH therapy in IJO and only one patient with documented IJO enrolled in the NCGS. Since IJO presents in the immediate prepubertal period and appears to improve naturally during puberty, it is difficult to differentiate the effects of GH therapy from those of puberty; therefore, we conclude that GH in IJO should currently be used only for research and not in clinical practice. |
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Authors:
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N M Wright |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of pediatric endocrinology & metabolism : JPEM Volume: 13 Suppl 2 ISSN: 0334-018X ISO Abbreviation: J. Pediatr. Endocrinol. Metab. Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2001-02-05 Completed Date: 2001-02-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9508900 Medline TA: J Pediatr Endocrinol Metab Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 999-1002 Citation Subset: IM |
Affiliation:
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Department of Pediatric Endocrinology, Tallahassee Memorial Hospital, FL 32308, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age of Onset Body Height* Child Clinical Trials as Topic Growth Hormone / therapeutic use* Humans Osteogenesis Imperfecta / drug therapy* Osteoporosis / drug therapy* |
| Chemical | |
Reg. No./Substance:
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9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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