Document Detail

Jun-B gene expression mediated by the surface immunoglobulin receptor of primary B lymphocytes.
MedLine Citation:
PMID:  1900155     Owner:  NLM     Status:  MEDLINE    
Stimulation of primary B lymphocytes induces the nuclear expression of TPA response element binding proteins that are recognized by anti-Jun antisera. To evaluate the profile of jun gene expression, RNA was extracted from B cells and probed for c-jun. Surprisingly, c-jun mRNA was not detected either before or after stimulation with anti-Ig. Instead, stimulation through the sIg antigen receptor, or with phorbol ester containing regimens, rapidly induced expression of the related jun-B. This demonstrates a lack of coordinate regulation for jun-B and c-jun expression in these primary B cells. The role of Jun-containing TRE binding proteins in promoting B cell cycle progression remains uncertain inasmuch as Jun-B has been associated with transcriptional inhibition of the TPA response element, rather than activation as produced by c-Jun.
J F Tilzey; T C Chiles; T L Rothstein
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  175     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-04-03     Completed Date:  1991-04-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  77-83     Citation Subset:  IM    
Evans Memorial Department of Clinical Research, Boston University Medical Center, MA 02118.
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MeSH Terms
B-Lymphocytes / immunology,  physiology*
Cell Membrane / physiology
Cells, Cultured
DNA-Binding Proteins / genetics*
Gene Expression / drug effects
Gene Expression Regulation
Mice, Inbred BALB C
Protein-Tyrosine Kinases / genetics
Proto-Oncogene Proteins / genetics
Proto-Oncogene Proteins c-fos
Proto-Oncogene Proteins c-jun
RNA, Messenger / genetics
Receptors, Immunologic / physiology*
Spleen / immunology
Transcription Factors / genetics
Grant Support
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/RNA, Messenger; 0/Receptors, Immunologic; 0/Transcription Factors; EC Kinases

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