Document Detail


Jumping translocations in multiple myeloma.
MedLine Citation:
PMID:  16102587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Jumping translocations (JT) have been defined as nonreciprocal translocations involving a same donor chromosome arm or chromosome segment onto two or more recipient chromosomes in different cell lines in the same patient, leading to a mosaic karyotype. This definition has been expanded to also include extra copies of a same donor segment on different recipient chromosomes in a single clone. Six patients with multiple myeloma and JT involving chromosome arm 1q were identified among 37 patients presenting with chromosome 1 abnormalities. All six patients had an advanced disease and a short survival. The literature review allowed us to identify 24 additional patients with JT. Chromosomes 16 and 19 were the recipients in 11 (45.8%) and 6 (25%) of these 24 patients, respectively. Breakpoints on the recipient chromosomes were pericentromeric in 46.2% and telomeric in 40.4% of the breakpoints recorded. Since telomeres are made of (TTAGGG)n tandem DNA repeats that are also found in the pericentromeric heterochromatic regions (interstital telomeric sequences), it is presumed that jumping translocations arise through illegimate recombination between telomere repeat sequences and interstitial telomeric sequences.
Authors:
Déborah Jamet; Youna Marzin; Nathalie Douet-Guilbert; Frédéric Morel; Marie-Josée Le Bris; Angèle Herry; Said Banzakour; Pascal Bourquard; Patrick Morice; Jean François Abgrall; Christian Berthou; Marc De Braekeleer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  161     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-16     Completed Date:  2005-10-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  159-63     Citation Subset:  IM    
Affiliation:
Laboratoire d'Histologie, Embryologie et Cytogénétique, Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale, 22 Avenue Camille Desmoulins, Brest cedex F-29285, France.
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MeSH Terms
Descriptor/Qualifier:
Aged
Chromosomes, Human, Pair 1*
Female
Humans
In Situ Hybridization, Fluorescence / methods
Male
Middle Aged
Multiple Myeloma / genetics*
Translocation, Genetic*

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