Document Detail


Jumping translocations of 1q in Burkitt lymphoma and acute nonlymphocytic leukemia.
MedLine Citation:
PMID:  8275449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
"Jumping translocations" have been observed mostly in cultured cells. Reports of such translocations in hematologic malignancies are few, and the associated clinical picture is unclear. We report three cases of hematologic malignancies with various unbalanced translocations (so-called jumping translocation) involving trisomy of the long arm of chromosome 1. The first case was a 13-year-old boy with Burkitt lymphoma who showed a very aggressive clinical course. The second case was a 10-month-old girl with acute nonlymphocytic leukemia [ANNL, French-American-British (FAB) classification M0] who had high risk factors, including hyperleukocytosis with a peripheral white blood cell (WBC) count of 300,000/microliters, and who died 7 months after diagnosis. The third case was a 6-year-old boy with Burkitt-like leukemia whose first remission lasted only 1 month. Only 10 cases with jumping translocations, including two cases with Burkitt-like leukemia/lymphoma, have been reported previously. This rare phenomenon may occur with increased frequency in Burkitt-like leukemia/lymphoma and may be an adverse prognostic factor.
Authors:
T Shikano; H Arioka; R Kobayashi; H Naito; Y Ishikawa
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  71     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-02-04     Completed Date:  1994-02-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  22-6     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Hokkaido University, Sapporo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Burkitt Lymphoma / genetics*
Child
Chromosomes, Human, Pair 1*
Female
Humans
Infant
Karyotyping
Leukemia, Myeloid, Acute / genetics*
Male
Translocation, Genetic*
Trisomy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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