Document Detail

Jugular venous oxygen saturation during mild hypothermic versus normothermic cardiopulmonary bypass in elderly patients.
MedLine Citation:
PMID:  15108076     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Age is known to be a major risk factor for adverse postoperative cognitive dysfunction after cardiac surgery. We conducted this study to determine if jugular venous oxygen saturation (SjvO(2)) differed during mild hypothermic (32 degrees C) and normothermic cardiopulmonary bypass (CPB) in elderly patients. METHODS: Sixty patients aged over 70 years who underwent elective coronary artery bypass grafting were randomly divided into two groups. Group 1 ( n = 30) underwent normothermic CPB (>35 degrees C) and group 2 ( n = 30) underwent mild hypothermic CPB (32 degrees C). For the continuous monitoring of SjvO(2), a fiberoptic oximetry oxygen saturation catheter was inserted into the right jugular bulb after the induction of anesthesia. Hemodynamic parameters, and arterial and jugular venous blood gases were measured at seven time points. RESULTS: The SjvO(2) in the normothermic group was lower at the onset of CPB and 20 min after the onset, than from the time of induction of anesthesia until the start of surgery (period 1), the respective SjvO(2) values being 50.3% +/- 1.0%, 50.1% +/- 1.6%, and 59.5% +/- 1.9% ( P < 0.05). However, in the mild hypothermic group there were no changes in the SjvO(2) value throughout the study. The cerebral desaturation time (when the SjvO(2) value was <50%) and the ratio of the cerebral desaturation time to the total CPB time in the normothermic group differed significantly from those in the hypothermic group, being 19 +/- 11 min and 17% +/- 10%, and 9 +/- 3 min and 8% +/- 4%, respectively ( P < 0.05). CONCLUSIONS: The SjvO(2) value was better during mild hypothermic CPB than during normothermic CPB in elderly patients.
Yuji Kadoi; Shigeru Saito; Ken-ichiro Takahashi; Nao Fujita; Fumio Goto
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Surgery today     Volume:  34     ISSN:  0941-1291     ISO Abbreviation:  Surg. Today     Publication Date:  2004  
Date Detail:
Created Date:  2004-04-26     Completed Date:  2004-09-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  399-404     Citation Subset:  IM    
Department of Intensive Care, Gunma University, Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.
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MeSH Terms
Body Temperature
Cardiopulmonary Bypass / methods*
Cerebrovascular Circulation*
Cognition Disorders / etiology
Coronary Artery Bypass
Hypothermia, Induced*
Jugular Veins*
Oxygen / blood*
Reg. No./Substance:

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