| Jugular venous and arterial concentrations of serum S-100B protein in patients with severe head injury: a pilot study. | |
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MedLine Citation:
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PMID: 9854976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to analyse the temporal course of the jugular venous-arterial gradient of S-100B protein after severe head injury and the correlation between the absolute concentrations of serum S-100B protein and outcome, CT findings, and clinical variables. Fifteen patients were included in this pilot study. All patients were treated according to a standard therapy protocol targeted to maintain cerebral perfusion pressure. The serum concentration of S-100 protein was measured daily for five consecutive days after injury by a monoclonal two site immunoluminometric assay. Nine patients showed favourable and six unfavourable outcome after 6 months with a mortality rate of 33% (five patients). The mean gradient between jugular venous and arterial blood was 8.2% (p<0.05). Patients showing an unfavourable outcome had significantly higher jugular venous or arterial S-100 values compared with those with a favourable outcome (jugular venous S-100B 2.78 microg/l v 1.22 microg/l, p<0.05; arterial S-100B 2.48 microg/l v 1.19 microg/l, p<0.05). All patients with an initial or secondary increase in S-100B value of >2 microg/l were found to have an unfavourable outcome. S-100B was found to be an independent predictor of outcome after severe head injury. The persisting increase of S-100B for three to five days even in patients with favourable outcome and no signs of secondary insults might reflect continuing damage to the blood-brain barrier or ongoing glial cell death. |
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Authors:
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A Raabe; D K Menon; S Gupta; M Czosnyka; J D Pickard |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 65 ISSN: 0022-3050 ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-01-07 Completed Date: 1999-01-07 Revised Date: 2008-11-20 |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 930-2 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Addenbrookes Hospital, University of Cambridge, England. araa@server3.medizin.uni-leipzig.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Blood Proteins / analysis* Blood-Brain Barrier Cell Death Craniocerebral Trauma / diagnosis* Female Glasgow Coma Scale Humans Jugular Veins / physiology* Male Pilot Projects Predictive Value of Tests Protein S / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Protein S |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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