Document Detail

Jugular bulb oxygen saturation under propofol or sevoflurane/nitrous oxide anesthesia during deliberate mild hypothermia in neurosurgical patients.
MedLine Citation:
PMID:  14676562     Owner:  NLM     Status:  MEDLINE    
Sevoflurane and propofol have been widely used as anesthetic agents for neurosurgery. Recent evidence has suggested that the influence of these anesthetics on cerebral oxygenation may differ. In the present study, the authors investigated jugular bulb oxygen saturation (SjO2) during propofol and sevoflurane/nitrous oxide anesthesia under mildly hypothermic conditions. After institutional approval and informed consent, 20 patients undergoing elective craniotomy were studied. Patients were randomly divided to the group S/N2O (sevoflurane/nitrous oxide/fentanyl anesthesia) or the group P (propofol/fentanyl anesthesia). After induction of anesthesia, the catheter was inserted retrograde into the jugular bulb and SjO2 was analyzed. During the operation, patients were cooled and tympanic membrane temperature was maintained at 34.5 degrees C. SjO2 was measured at normocapnia during mild hypothermia and at hypocapnia during mild hypothermia. There were no statistically significant differences in demographic variables between the groups. During mild hypothermia, SjO2 values were significantly lower in group P than in group S/N2O. The incidence of SjO2 less than 50% under mild hypothermic-hypocapnic conditions was significantly higher in group P than in group S/N2O. These results suggest that hyperventilation should be more cautiously applied during mild hypothermia in patients anesthetized with propofol and fentanyl versus sevoflurane/nitrous oxide/fentanyl.
Yasunobu Kawano; Masahiko Kawaguchi; Satoki Inoue; Toshinori Horiuchi; Takanori Sakamoto; Kenji Yoshitani; Hitoshi Furuya; Toshisuke Sakaki
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of neurosurgical anesthesiology     Volume:  16     ISSN:  0898-4921     ISO Abbreviation:  J Neurosurg Anesthesiol     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-16     Completed Date:  2004-04-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8910749     Medline TA:  J Neurosurg Anesthesiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6-10     Citation Subset:  IM    
Department of Anesthesiology, Nara Medical Facility, Kashihara, Nara, Japan.
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MeSH Terms
Analysis of Variance
Anesthetics, Combined / pharmacology
Anesthetics, Inhalation / pharmacology
Anesthetics, Intravenous / pharmacology
Blood Gas Analysis
Hypocapnia / blood,  etiology
Hypothermia, Induced*
Jugular Veins / drug effects,  physiology*
Methyl Ethers / pharmacology*
Middle Aged
Neurosurgical Procedures
Nitrous Oxide / pharmacology*
Oxygen / blood*
Propofol / pharmacology*
Reg. No./Substance:
0/Anesthetics, Combined; 0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 0/Methyl Ethers; 10024-97-2/Nitrous Oxide; 2078-54-8/Propofol; 28523-86-6/sevoflurane; 7782-44-7/Oxygen

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