Document Detail

Joint tenderness and swelling in biologic-treated inflammatory arthritis patients - a tricky trade off?
MedLine Citation:
PMID:  22257038     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the pattern of joint responses in patients with rheumatoid arthritis and psoriatic arthritis treated with TNF inhibitor (TNFi) therapy.
METHODS: A total of 182 PsA/Rheumatoid arthritis (RA) patients attending the rheumatology unit of a tertiary referral centre in Ireland were recruited and prospectively followed up by the attendant rheumatologists. Clinical progress of the patients was noted at baseline and 6 months after starting TNFi therapy.
RESULTS: A total of 114 RA and 68 PsA patients were assessed; 20% of the patients had one of either tender joints or swollen joints after 6 months of therapy. Rheumatoid arthritis patients had a significantly higher proportion of non-tender swollen joints compared with PsA patients, whereas PsA patients had a higher proportion of tender non-swollen joints (p < 0.05).
CONCLUSION: Residual joint swelling was found more commonly in RA patients than in PsA patients following TNFi therapy, whereas residual tender joints occurred more frequently in PsA; this may reflect enthesiopathy or periostitis.
L C Harty; C T Ng; C Fearon; C A Murray; O Fitzgerald; D J Veale
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of clinical practice     Volume:  66     ISSN:  1742-1241     ISO Abbreviation:  Int. J. Clin. Pract.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-19     Completed Date:  2012-03-13     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  9712381     Medline TA:  Int J Clin Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  128-31     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Bone and Joint Unit, Department of Rheumatology, St Vincent's University Hospital, Dublin, Ireland.
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MeSH Terms
Antibodies, Monoclonal / adverse effects
Antibodies, Monoclonal, Humanized / adverse effects
Antirheumatic Agents / adverse effects*
Arthralgia / chemically induced*
Arthritis, Psoriatic / drug therapy*
Arthritis, Rheumatoid / drug therapy*
Edema / chemically induced*
Immunoglobulin G / adverse effects
Middle Aged
Prospective Studies
Receptors, Tumor Necrosis Factor
Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/Antirheumatic Agents; 0/Immunoglobulin G; 0/Receptors, Tumor Necrosis Factor; 0/Tumor Necrosis Factor-alpha; 0/infliximab; 185243-69-0/TNFR-Fc fusion protein; FYS6T7F842/adalimumab

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