Document Detail

Joint formation requires muscle formation and contraction.
MedLine Citation:
PMID:  19460337     Owner:  NLM     Status:  MEDLINE    
Embryo movement and muscle contraction affect joint formation, but their precise roles have remained elusive. In this issue of Developmental Cell, Joy Kahn and coworkers now demonstrate that these processes are essential for joint formation. They find that joint progenitor cells are unable to remain committed to their specified cell fate in mutant mice with defects in either muscle formation or contraction.
Hideyo Yasuda; Benoit de Crombrugghe
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Developmental cell     Volume:  16     ISSN:  1878-1551     ISO Abbreviation:  Dev. Cell     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-22     Completed Date:  2009-06-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  625-6     Citation Subset:  IM    
Department of Genetics, Unit 1006, M.D. Anderson Cancer Center, University of Texas, Houston, TX 77030, USA.
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MeSH Terms
Cell Differentiation
Extremities / embryology,  physiology
Joints / cytology,  embryology*
Muscle Contraction*
Muscle, Skeletal / physiology
Stem Cells / cytology
Comment On:
Dev Cell. 2009 May;16(5):734-43   [PMID:  19460349 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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