| Joint effects of cigarette smoking and irradiation in pregnant mice and their offspring. | |
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MedLine Citation:
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PMID: 19414412 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We have previously reported that irradiation of mice in utero significantly increased the tumor incidence in the offspring of irradiated mothers. The joint effects of irradiation and cigarette smoking (CS) on tumor incidence and on the process of carcinogenesis were investigated. MATERIALS AND METHODS: Pregnant C57Bl/6J female mice were irradiated with a single dose of gamma-ray (1 Gy or 3 Gy) and/or exposed to CS of IR3 non-filtered cigarettes before or during pregnancy, tumors were investigated both with histological and immunohistochemical methods. RESULTS: Longer exposure (60 days) of the mice to CS before pregnancy and irradiation during pregnancy significantly increased the tumor incidence in the mothers and their offspring. Parallel activation of Caspase-8 and inactivation of Caspase-9 was found. CONCLUSION: Joint exposure of mice to prolonged CS before pregnancy and irradiation during pregnancy significantly increased the tumor incidence both in the mothers and their offspring. |
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Authors:
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Sára Antal; Béla Szende; József Lengyel; Egon J Hidvégi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: In vivo (Athens, Greece) Volume: 23 ISSN: 0258-851X ISO Abbreviation: In Vivo Publication Date: 2009 Mar-Apr |
Date Detail:
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Created Date: 2009-05-05 Completed Date: 2009-07-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8806809 Medline TA: In Vivo Country: Greece |
Other Details:
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Languages: eng Pagination: 267-72 Citation Subset: IM |
Affiliation:
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Radiobiological Foundation, Budapest, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caspase 8 / metabolism Caspase 9 / metabolism Enzyme Activation Female Gamma Rays / adverse effects* Male Maternal Exposure* Mice Mice, Inbred C57BL Mice, Inbred DBA Neoplasms / etiology, prevention & control Pregnancy Pregnancy, Animal Smoking / adverse effects* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.22.-/Caspase 8; EC 3.4.22.-/Caspase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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