| Joint effect of white matter lesions and hippocampal volumes on severity of cognitive decline: the 3C-Dijon MRI study. | |
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MedLine Citation:
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PMID: 20164560 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several brain magnetic resonance imaging (MRI) changes are observed in older individuals including white matter lesions (WML), silent brain infarcts (SBI), and cerebral atrophy. Few studies, however, have assessed the combined association of these changes on the severity of future cognitive decline. In the prospective population-based 3C-Dijon MRI study, 1701 non-demented participants aged 65 to 80 years at entry had a brain MRI. Information on WML, hippocampal volumes, SBI presence, and brain parenchymal fraction were obtained. At 4-year follow-up, participants were screened for cognitive decline and dementia. Severity of cognitive decline was defined as none, moderate, or severe calculated from neuropsychological test performance change. The relation between brain MRI markers and longitudinal change in cognition was studied using polytomous logistic regression and multiple linear regression models controlling for potential confounders. Two-by-two interactions were tested including with the apolipoprotein E genotype. At follow-up, 46 participants showed severe cognitive deterioration and 224 participants showed moderate cognitive deterioration. In multivariable analyses, risk of severe cognitive deterioration as well as the cognitive decline rate were significantly increased in participants with higher WML volume (p< 0.01) and smaller hippocampal volume (p< 0.01). The results suggested that WML and hippocampal volumes had a cumulative effect on the future level of cognitive decline. The APOE genotype was found to be an effect modifier of this association. Vascular brain changes and degenerative processes coexist in normal older individuals. The co-occurrence of degenerative and non-degenerative pathologies could strongly affect the course of dementia expression. |
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Authors:
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Ophélia Godin; Christophe Tzourio; Olivier Rouaud; Yicheng Zhu; Pauline Maillard; Florence Pasquier; Fabrice Crivello; Annick Alpérovitch; Bernard Mazoyer; Carole Dufouil |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of Alzheimer's disease : JAD Volume: 20 ISSN: 1875-8908 ISO Abbreviation: J. Alzheimers Dis. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-05-27 Completed Date: 2010-09-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9814863 Medline TA: J Alzheimers Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 453-63 Citation Subset: IM |
Affiliation:
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Inserm, U708 Neuroepidemiology, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Cognition Disorders / pathology* Female Hippocampus / pathology* Humans Imaging, Three-Dimensional* / methods Linear Models Longitudinal Studies Magnetic Resonance Imaging* Male Mental Status Schedule Middle Aged Nerve Fibers, Myelinated / pathology* Neuropsychological Tests Retrospective Studies Severity of Illness Index |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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