Document Detail

Jiangxienone, a New Compound with Potent Cytotoxicity against Tumor Cells from Traditional Chinese Medicinal Mushroom Cordyceps jiangxiensis.
MedLine Citation:
PMID:  22782880     Owner:  NLM     Status:  In-Data-Review    
A new compound, named jiangxienone, has been isolated from a culture of the traditional Chinese medicinal mushroom Cordyceps jiangxiensis, and its chemical structure was established on the basis of spectroscopic and chemical techniques. Jiangxienone showed potent cytotoxic effects against human gastric adenocarcinoma SGC-7901 cell and human lung carcinoma A549 cell with IC(50) values ranging from 1.38 to 2.93 μM, i.e., with at least approximately six-fold stronger cytotoxicity than cisplatin, a first-line chemotherapy drug for cancer patients.
Jian-Hui Xiao; Zhong-Hua Sun; Wei-Dong Pan; Yu-Hong Lü; Dai-Xiong Chen; Jian-Jiang Zhong
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemistry & biodiversity     Volume:  9     ISSN:  1612-1880     ISO Abbreviation:  Chem. Biodivers.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197449     Medline TA:  Chem Biodivers     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1349-55     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Verlag Helvetica Chimica Acta AG, Zürich.
Division of Applied Mycology and Biochemical Pharmacy, Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical College, Zunyi 563000, P. R. China; State Key Laboratory of Bioreactor Engineering, East China University of Science & Technology, Shanghai 200237, P. R. China.
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