| The Jewish Hospital of St. Louis therapeutic grand rounds number 10. Chemoprophylaxis of tuberculosis. | |
MedLine Citation:
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PMID: 1138677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Isoniazid therapy has been proved an effective means of preventing overt clinical tuberculosis in persons with positive tuberculin skin tests, persons who are close contacts of active cases, and persons with inactive tuberculosis that were never treated. The administration of isoniazid in standard dosage for one year in these situations will help greatly to reduce tuberculosis as a community health problem in the future. Studies in recent years, however, point to hepatic dysfunction as a complication of isoniazid therapy in up to 10% of patients. In a few patients, liver disease as a complication of this therapy has been fatal. The likelihood of this complication increases with age. Accordingly, isoniazid chemoprophylaxis should be undertaken with the understanding that the patient has to be followed up closely, especially for evidence of liver disease during the course of therapy. This potentially serious side effect suggests that isoniazid chemoprophylaxis should be used primarily with patients in high risk groups. |
Authors:
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S S Lefrak; R Byrd; R M Senior; L V Avioli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of internal medicine Volume: 135 ISSN: 0003-9926 ISO Abbreviation: Arch. Intern. Med. Publication Date: 1975 Apr |
Date Detail:
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Created Date: 1975-09-09 Completed Date: 1975-09-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 606-11 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult BCG Vaccine* Ethambutol / therapeutic use Humans Isoniazid / adverse effects, therapeutic use* Male Neuritis Streptomycin / therapeutic use Tuberculin Test Tuberculosis, Pulmonary / drug therapy, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/BCG Vaccine; 54-85-3/Isoniazid; 57-92-1/Streptomycin; 74-55-5/Ethambutol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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