Document Detail

The Jewish Hospital of St. Louis therapeutic grand rounds number 10. Chemoprophylaxis of tuberculosis.
MedLine Citation:
PMID:  1138677     Owner:  NLM     Status:  MEDLINE    
Isoniazid therapy has been proved an effective means of preventing overt clinical tuberculosis in persons with positive tuberculin skin tests, persons who are close contacts of active cases, and persons with inactive tuberculosis that were never treated. The administration of isoniazid in standard dosage for one year in these situations will help greatly to reduce tuberculosis as a community health problem in the future. Studies in recent years, however, point to hepatic dysfunction as a complication of isoniazid therapy in up to 10% of patients. In a few patients, liver disease as a complication of this therapy has been fatal. The likelihood of this complication increases with age. Accordingly, isoniazid chemoprophylaxis should be undertaken with the understanding that the patient has to be followed up closely, especially for evidence of liver disease during the course of therapy. This potentially serious side effect suggests that isoniazid chemoprophylaxis should be used primarily with patients in high risk groups.
S S Lefrak; R Byrd; R M Senior; L V Avioli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  135     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1975 Apr 
Date Detail:
Created Date:  1975-09-09     Completed Date:  1975-09-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  606-11     Citation Subset:  AIM; IM    
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MeSH Terms
BCG Vaccine*
Ethambutol / therapeutic use
Isoniazid / adverse effects,  therapeutic use*
Streptomycin / therapeutic use
Tuberculin Test
Tuberculosis, Pulmonary / drug therapy,  prevention & control*
Reg. No./Substance:
0/BCG Vaccine; 54-85-3/Isoniazid; 57-92-1/Streptomycin; 74-55-5/Ethambutol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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