| Jejunal responses to absorptive and secretory stimuli in the neurally isolated jejunum in vivo. | |
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MedLine Citation:
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PMID: 8079188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Our aim was to assess changes in transport of water and electrolytes under basal, proabsorptive, and prosecretory conditions after an in situ neural isolation of the jejunoileum. METHODS: Eight dogs underwent intraoperative perfusion of 50 cm of jejunum with a balanced electrolyte solution during sham operation and after neural isolation of the jejunoileum. Jejunal perfusion studies were later conducted in seven conscious dogs with a triple-lumen technique before and 2 and 8 weeks after neural isolation of the jejunoileum during intravenous infusion of 150 mmol/L sodium chloride (basal conditions), vasoactive intestinal polypeptide (VIP conditions), 500 pmol/kg per hour (prosecretory conditions), and the alpha 2-adrenergic agonist alpha-methylnorepinephrine (MNE), 900 nmol/kg per hour (proabsorptive conditions). RESULTS: Neural isolation decreased intraoperative net absorption of water (4.4 +/- 0.9 vs 2.2 +/- 0.5 microliters/cm/min; p < 0.05) and electrolytes (sodium, chloride, bicarbonate, potassium). In conscious dogs during basal conditions, net absorptive flux was decreased (p < 0.05) at 2 but not at 8 weeks. VIP produced similar absolute decreases in net absorptive flux at all three time points. MNE increased net absorption before and at 8 weeks, but not at 2 weeks after autotransplantation. CONCLUSIONS: In situ neural isolation of the jejunoileum decreased net basal jejunal absorption of water and electrolytes immediately and for at least 2 weeks. Proabsorptive responses to MNE but not prosecretory responses to VIP were altered at 2 weeks. Jejunal adaptation allowed absorptive function to return to near normal by 8 weeks. |
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Authors:
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S M Herkes; C D Smith; M G Sarr |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Surgery Volume: 116 ISSN: 0039-6060 ISO Abbreviation: Surgery Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1994-09-30 Completed Date: 1994-09-30 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 576-86 Citation Subset: AIM; IM |
Affiliation:
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Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Water / metabolism Dogs Electrolytes / metabolism Female Ileum / drug effects, innervation, metabolism Intestinal Absorption / drug effects, physiology* Jejunum / drug effects, innervation, metabolism* Nordefrin / pharmacology Perfusion Time Factors Vasoactive Intestinal Peptide / physiology |
| Grant Support | |
ID/Acronym/Agency:
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DK39337/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Electrolytes; 37221-79-7/Vasoactive Intestinal Peptide; 6539-57-7/Nordefrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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