Document Detail

Jejunal responses to absorptive and secretory stimuli in the neurally isolated jejunum in vivo.
MedLine Citation:
PMID:  8079188     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Our aim was to assess changes in transport of water and electrolytes under basal, proabsorptive, and prosecretory conditions after an in situ neural isolation of the jejunoileum. METHODS: Eight dogs underwent intraoperative perfusion of 50 cm of jejunum with a balanced electrolyte solution during sham operation and after neural isolation of the jejunoileum. Jejunal perfusion studies were later conducted in seven conscious dogs with a triple-lumen technique before and 2 and 8 weeks after neural isolation of the jejunoileum during intravenous infusion of 150 mmol/L sodium chloride (basal conditions), vasoactive intestinal polypeptide (VIP conditions), 500 pmol/kg per hour (prosecretory conditions), and the alpha 2-adrenergic agonist alpha-methylnorepinephrine (MNE), 900 nmol/kg per hour (proabsorptive conditions). RESULTS: Neural isolation decreased intraoperative net absorption of water (4.4 +/- 0.9 vs 2.2 +/- 0.5 microliters/cm/min; p < 0.05) and electrolytes (sodium, chloride, bicarbonate, potassium). In conscious dogs during basal conditions, net absorptive flux was decreased (p < 0.05) at 2 but not at 8 weeks. VIP produced similar absolute decreases in net absorptive flux at all three time points. MNE increased net absorption before and at 8 weeks, but not at 2 weeks after autotransplantation. CONCLUSIONS: In situ neural isolation of the jejunoileum decreased net basal jejunal absorption of water and electrolytes immediately and for at least 2 weeks. Proabsorptive responses to MNE but not prosecretory responses to VIP were altered at 2 weeks. Jejunal adaptation allowed absorptive function to return to near normal by 8 weeks.
S M Herkes; C D Smith; M G Sarr
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Surgery     Volume:  116     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-09-30     Completed Date:  1994-09-30     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  576-86     Citation Subset:  AIM; IM    
Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905.
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MeSH Terms
Body Water / metabolism
Electrolytes / metabolism
Ileum / drug effects,  innervation,  metabolism
Intestinal Absorption / drug effects,  physiology*
Jejunum / drug effects,  innervation,  metabolism*
Nordefrin / pharmacology
Time Factors
Vasoactive Intestinal Peptide / physiology
Grant Support
Reg. No./Substance:
0/Electrolytes; 37221-79-7/Vasoactive Intestinal Peptide; 6539-57-7/Nordefrin

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