Document Detail

Jejunal pouch reconstruction but not preservation of duodenal passage after total gastrectomy reduces plasma cholecystokinin and pancreatic polypeptide long term in pigs.
MedLine Citation:
PMID:  19368131     Owner:  NLM     Status:  MEDLINE    
AIM: The long-term effects of reconstructions of the gastrointestinal tract after gastrectomy on plasma levels of gastrointestinal hormones that contribute to food intake controls were evaluated. MATERIALS AND METHODS: Domestic pigs were randomly assigned to sham-surgery or total gastrectomy followed by reconstruction with oesophagojejunostomy on a Roux-en-Y loop (OJRY), jejunal interposition between the oesophagus and the duodenum (OJD), or an oesophagojejunostomy with a jejunal pouch reservoir (J-pouch) on a Roux-en-Y loop. Plasma levels of peptides were analysed by radioimmunoassay (RIA). RESULTS: Ten weeks after surgery, levels of cholecystokinin (CCK) and pancreatic polypeptide (PP) were significantly lowered (79.6% and 67.0%, respectively) in animals with a J-pouch, but not in sham-operated animals or animals with OJRY or OJD, as compared to preoperative levels. The levels of neuropeptide Y (NPY) and peptide YY (PYY) remained unchanged, irrespective of the mode of reconstruction. CONCLUSION: J-pouch, but not preservation of duodenal passage after total gastrectomy, lowers levels of CCK and PP, peptides that reduce food intake.
Ulrika Smedh; Lars Hansson; Rolf Ekman; Thomas Zilling
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  23     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    2009 Jan-Feb
Date Detail:
Created Date:  2009-04-16     Completed Date:  2009-05-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  93-8     Citation Subset:  IM    
Department of Surgery, Lund University Hospital, Lund, Sweden.
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MeSH Terms
Anastomosis, Roux-en-Y*
Body Weight
Cholecystokinin / blood*
Colonic Pouches*
Disease Models, Animal
Duodenum / surgery
Esophagus / surgery
Jejunum / surgery
Neuropeptide Y / blood
Nutritional Status
Pancreatic Polypeptide / blood*
Peptide YY / blood
Postgastrectomy Syndromes / blood*,  pathology
Reg. No./Substance:
0/Neuropeptide Y; 106388-42-5/Peptide YY; 59763-91-6/Pancreatic Polypeptide; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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