| Jejunal macromolecular absorption and bile salt deconjugation in protein-energy malnourished rats. | |
| | |
MedLine Citation:
|
PMID: 6789664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The combined stress of protein-energy malnutrition (PEM) and exposure of the jejunum to pathophysiological (0.5 mM) levels of a bacterial metabolite, deconjugated bile salts, led to alterations not apparent with either stress alone. Perfusion of the jejunum of PEM rats with 0.5 mM deoxycholate (DCh) and a 40,000 dalton macromolecular tracer, horseradish peroxidase, led to higher serum horseradish peroxidase levels than were seen in PEM rats not exposed to DCh or in well-nourished controls treated with DCh. Semiquantitative cytochemical analysis indicated an increased number of villi with horseradish peroxidase penetration in PEM rats treated with 0.5 mM DCh. DCh perfusion of PEM rats also produced fine structural damage to epithelial cells not apparent in other preparations. And, perfusion with 0.5 mM cholate only produced sodium secretion in PEM rats. These observations in an animal model of PEM suggest that malnourished children with a colonic type of bacterial overgrowth of the small bowel may attain increased levels of foreign antigens or toxins from the intestinal lumen. |
| | |
Authors:
|
S Teichberg; U Fagundes-Neto; M A Bayne; F Lifshitz |
Related Documents
:
|
3339874 - In vivo isolated liver perfusion technique in a rat hepatic metastasis model: 5-fluorou... 2859104 - Comparison of somatostatin-28 and somatostatin-14 clearance by the perfused rat liver. 16317694 - A role for asymmetric dimethylarginine in the pathophysiology of portal hypertension in... 22258084 - Lung hypoplasia in rats with esophageal atresia and tracheo-esophageal fistula. 485634 - Effects of estradiol-17 beta on reproduction in adult male rats. 3667104 - Serotonin and kindling development. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The American journal of clinical nutrition Volume: 34 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1981 Jul |
Date Detail:
|
Created Date: 1981-09-15 Completed Date: 1981-09-15 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1281-91 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bile Acids and Salts / metabolism* Chemical Phenomena Chemistry Cholic Acids / metabolism Deoxycholic Acid / metabolism Epithelium / ultrastructure Horseradish Peroxidase / metabolism* Intestinal Absorption / drug effects Intestinal Mucosa / physiopathology Jejunum / microbiology, physiopathology*, ultrastructure Male Peroxidases / metabolism* Protein-Energy Malnutrition / metabolism* Rats Sodium / metabolism Taurocholic Acid / metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
1 SO8 RR 09128-02/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Bile Acids and Salts; 0/Cholic Acids; 7440-23-5/Sodium; 81-24-3/Taurocholic Acid; 83-44-3/Deoxycholic Acid; EC 1.11.1.-/Horseradish Peroxidase; EC 1.11.1.-/Peroxidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Alkalosis-induced coronary vasoconstriction: effects of calcium, diltiazem, nitroglycerin, and propr...
Next Document: Utilization and metabolic effects of a conventional and a single-solution regimen in postoperative t...