| Jejunal-ileal differences in dopaminergic but not alpha-adrenergic antisecretory effects. | |
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MedLine Citation:
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PMID: 2983568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clonidine, an alpha-adrenergic agonist, and apomorphine, a dopaminergic agonist, inhibit water secretion in rat intestine induced by dibutyryl cAMP (DBcAMP) in situ. Apomorphine reversed DBcAMP-induced secretion in ileum and jejunum with ED50 values of 90 and 200 nM, respectively. ED50 values for clonidine's antisecretory effect were 32 and 2 microM in ileum and jejunum, respectively. The antisecretory effects of both clonidine and apomorphine were blocked by the alpha-adrenergic antagonist phentolamine and by the dopaminergic antagonists halo-peridol and sulpiride. Phentolamine was about 10-fold more potent against clonidine than against apomorphine in the ileum and the jejunum. Haloperidol and sulpiride were at least 10-fold more potent against apomorphine than against clonidine in the ileum. In contrast, in the jejunum, haloperidol was equally potent in blocking effects of both agonists, while sulpiride did not block the apomorphine effect. The data are consistent with the presence of both alpha 2-adrenergic and DA2-dopaminergic receptors that stimulate absorption in the ileum. In the jejunum, antisecretory effect appears to be mediated by an action on either an alpha 2-adrenergic or a dopaminergic receptor with characteristics different from those of peripheral DA1- or DA2-receptors. |
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Authors:
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R Wahawisan; T S Gaginella; L J Wallace |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 248 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1985 Mar |
Date Detail:
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Created Date: 1985-04-08 Completed Date: 1985-04-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: G332-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apomorphine / pharmacology Bucladesine / pharmacology Clonidine / pharmacology Haloperidol / pharmacology Ileum / metabolism* Intestinal Absorption* Jejunum / metabolism* Male Phentolamine / pharmacology Rats Rats, Inbred Strains Receptors, Adrenergic, alpha / drug effects, metabolism* Receptors, Dopamine / drug effects, metabolism* Sulpiride / pharmacology Water-Electrolyte Balance |
| Grant Support | |
ID/Acronym/Agency:
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AM-28299/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic, alpha; 0/Receptors, Dopamine; 15676-16-1/Sulpiride; 362-74-3/Bucladesine; 4205-90-7/Clonidine; 50-60-2/Phentolamine; 52-86-8/Haloperidol; 58-00-4/Apomorphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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