| Jejunal dopamine and Na,K+-ATPase activity in nephrotic syndrome. | |
| | |
MedLine Citation:
|
PMID: 16088079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The occurrence of complementary functions in sodium transport between the intestine and the kidney was suggested to occur when the renal function is immature or compromised and jejunal dopamine has been implicated in this renal-intestinal cross-talk. The jejunal sodium transport was not previously evaluated in the nephrotic syndrome. METHODS: We examined the jejunal Na(+),K(+)-ATPase activity and the role of dopamine in puromycin aminonucleoside (PAN) and HgCl(2)-induced nephrotic syndrome rat models. RESULTS: In both nephrotic syndrome rat models, the jejunal Na(+),K(+)-ATPase activity was reduced during greatest sodium retention and ascites accumulation (PAN nephrosis, day 7; HgCl(2) nephrosis, day 14), whereas during enhanced sodium excretion and ascites mobilization the jejunal Na(+),K(+)-ATPase activity was increased in HgCl(2) nephrosis (day 21) and was similar to controls in PAN nephrosis (day 14). In both PAN- and HgCl(2)-induced nephrosis, the jejunal aromatic L-amino acid decarboxylase (AADC) activity, the enzyme responsible for the synthesis of jejunal dopamine, did not differ from controls. In addition, the jejunal Na(+),K(+)-ATPase activity was not sensitive to inhibition by dopamine (1 microM) in both experimental groups throughout the study. CONCLUSIONS: In the nephrotic syndrome the jejunal Na(+),K(+)-ATPase activity may respond in a compensatory way to changes in extracellular volume, through dopamine-independent mechanisms. |
| | |
Authors:
|
B Sampaio-Maia; M Moreira-Rodrigues; P Serrão; M Pestana |
Related Documents
:
|
12708949 - Combined furosemide and human albumin treatment for diuretic-resistant edema. 6731499 - Use of noninvasive laboratory testing in the prediction of thrombosis in the nephrotic ... 15692629 - Cyclosporin a therapy in a case with hyperimmunoglobulin e and nephrotic syndrome. 11928729 - Nephrotic syndrome: more than just oedema. 16825089 - Ace gene polymorphism in turkish children with nephrotic syndrome. 7696099 - Applying decision analysis to management of adolescent idiopathic nephrotic syndrome. 6609699 - Autoantibodies to small nuclear ribonucleoproteins. a strong association between anti-s... 9804119 - Fisher's syndrome and group a streptococcal infection. 3595659 - Pontine infarction producing dysarthria-clumsy hand syndrome and ataxic hemiparesis. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-07-25 |
Journal Detail:
|
Title: American journal of nephrology Volume: 25 ISSN: 0250-8095 ISO Abbreviation: Am. J. Nephrol. Publication Date: 2005 Jul-Aug |
Date Detail:
|
Created Date: 2005-08-16 Completed Date: 2005-11-22 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8109361 Medline TA: Am J Nephrol Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 382-92 Citation Subset: IM |
Copyright Information:
|
Copyright 2005 S. Karger AG, Basel. |
Affiliation:
|
Institute of Pharmacology and Therapeutics, Faculty of Medicine, Porto, Portugal. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Dopamine / metabolism* Jejunum / metabolism* Kidney / metabolism Male Models, Animal Nephrotic Syndrome / metabolism* Rats Rats, Sprague-Dawley Sodium-Potassium-Exchanging ATPase / metabolism* |
| Chemical | |
Reg. No./Substance:
|
EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: CD2AP expression in a renal ischemia/reperfusion injury model and analysis of its related genes usin...
Next Document: Angiotensin receptor blockade and arterial compliance in chronic kidney disease: a pilot study.