Document Detail


Jaw and branchial arch mutants in zebrafish I: branchial arches.
MedLine Citation:
PMID:  9007253     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Jaws and branchial arches together are a basic, segmented feature of the vertebrate head. Seven arches develop in the zebrafish embryo (Danio rerio), derived largely from neural crest cells that form the cartilaginous skeleton. In this and the following paper we describe the phenotypes of 109 arch mutants, focusing here on three classes that affect the posterior pharyngeal arches, including the hyoid and five gill-bearing arches. In lockjaw, the hyoid arch is strongly reduced and subsets of branchial arches do not develop. Mutants of a large second class, designated the flathead group, lack several adjacent branchial arches and their associated cartilages. Five alleles at the flathead locus all lead to larvae that lack arches 4-6. Among 34 other flathead group members complementation tests are incomplete, but at least six unique phenotypes can be distinguished. These all delete continuous stretches of adjacent branchial arches and unpaired cartilages in the ventral midline. Many show cell death in the midbrain, from which some neural crest precursors of the arches originate. lockjaw and a few mutants in the flathead group, including pistachio, affect both jaw cartilage and pigmentation, reflecting essential functions of these genes in at least two neural crest lineages. Mutants of a third class, including boxer, dackel and pincher, affect pectoral fins and axonal trajectories in the brain, as well as the arches. Their skeletal phenotypes suggest that they disrupt cartilage morphogenesis in all arches. Our results suggest that there are sets of genes that: (1) specify neural crest cells in groups of adjacent head segments, and (2) function in common genetic pathways in a variety of tissues including the brain, pectoral fins and pigment cells as well as pharyngeal arches.
Authors:
T F Schilling; T Piotrowski; H Grandel; M Brand; C P Heisenberg; Y J Jiang; D Beuchle; M Hammerschmidt; D A Kane; M C Mullins; F J van Eeden; R N Kelsh; M Furutani-Seiki; M Granato; P Haffter; J Odenthal; R M Warga; T Trowe; C Nüsslein-Volhard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  123     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-02-11     Completed Date:  1997-02-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  329-44     Citation Subset:  IM    
Affiliation:
Imperial Cancer Research Fund, London, UK. schillin@icrf.icnet.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Branchial Region / abnormalities,  embryology*
Extremities / embryology
Facial Bones / embryology
Hyoid Bone / embryology
Jaw / embryology*
Limb Deformities, Congenital
Mesencephalon / abnormalities,  embryology
Mouth / embryology
Mutation*
Necrosis
Pharynx / abnormalities,  embryology
Phenotype
Pigmentation / genetics
Skull / embryology
Superior Colliculi / abnormalities,  embryology
Zebrafish / embryology*,  genetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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