Document Detail


Jaundice.
MedLine Citation:
PMID:  7207902     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Jaundice is caused by an increase in bilirubin in the blood. This can occur before the bilirubin is conjugated by the liver, or after the bilirubin has been conjugated. If the bilirubin has not yet ben conjugated, it will not be able to pass through lipid membranes and will not be soluble in water. Therefore it will not be present in urine. Increases in conjugated bilirubin by the liver, or problems in the conjugation itself. If the increase is conjugated bilirubin, the disorder lies within the outlet channels of the hepatocyte, or there is some kind of obstruction in the biliary outlet system. Within the liver itself, the most common causes of difficulty are acute and chronic hepatitis, alcoholic cirrhosis and drug-induced liver dysfunction. Extra-hepatic obstructions are usually associated with the gall bladder, but may result from tumors of sclerosing secondary to chronic bowel disease.
Authors:
M B Myers
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Nurse practitioner     Volume:  6     ISSN:  0361-1817     ISO Abbreviation:  Nurse Pract     Publication Date:    1981 Mar-Apr
Date Detail:
Created Date:  1981-05-21     Completed Date:  1981-05-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603663     Medline TA:  Nurse Pract     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8-12, 27     Citation Subset:  IM; N    
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MeSH Terms
Descriptor/Qualifier:
Bilirubin / biosynthesis,  blood
Cholestasis, Extrahepatic / blood
Humans
Infant, Newborn
Jaundice / blood*,  diagnosis
Jaundice, Neonatal / blood
Liver / metabolism
Liver Diseases / blood
Chemical
Reg. No./Substance:
635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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