| Jaundice predicts advanced disease and early mortality in patients with gallbladder cancer. | |
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MedLine Citation:
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PMID: 14993027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In patients with gallbladder cancer, jaundice suggests tumor involvement of the porta hepatis. This study reports on the prevalence, etiology, and clinical significance of jaundice in patients with gallbladder cancer. METHODS: Patients who presented with gallbladder cancer from 1995 to 2002 were entered into a prospective database. Disease-specific survival and clinicopathologic correlates were analyzed. RESULTS: Eighty-two (34%) of 240 patients with gallbladder cancer presented with jaundice. Jaundiced patients (96%) were more likely (P <.001) to have advanced-stage disease than nonjaundiced patients (60%). Only six (7%) jaundiced patients were resected with curative intent, and only four (5%) had negative surgical margins. This was significantly different from the nonjaundiced group, in which 62 patients (39%) had negative margins (P <.001). The median disease-specific survival in patients presenting with jaundice was 6 months and was significantly lower compared with 16 months in patients without jaundice (P <.0001). In the group presenting with jaundice, there were no disease-free survivors at 2 years, compared with 21% in the group without jaundice. CONCLUSIONS: Jaundice is common (34%) in patients who present with gallbladder cancer and is an indicator of advanced malignancy. These data do not support routine operative exploration of patients with jaundice secondary to gallbladder cancer. |
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Authors:
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William G Hawkins; Ronald P DeMatteo; William R Jarnagin; Leah Ben-Porat; Leslie H Blumgart; Yuman Fong |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of surgical oncology Volume: 11 ISSN: 1068-9265 ISO Abbreviation: Ann. Surg. Oncol. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-02 Completed Date: 2004-06-01 Revised Date: 2007-07-18 |
Medline Journal Info:
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Nlm Unique ID: 9420840 Medline TA: Ann Surg Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 310-5 Citation Subset: IM |
Affiliation:
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Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Databases, Factual Female Gallbladder Neoplasms / pathology*, surgery* Humans Jaundice / etiology*, pathology Male Middle Aged Neoplasm Staging* Prognosis Prospective Studies Risk Factors Survival Analysis Treatment Outcome |
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