| Jaundice in severe bacterial infection. | |
| | |
MedLine Citation:
|
PMID: 1278654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Thirty patients are described who developed jaundice during the course of severe bacterial infection. Although the infecting organism was variable, as was the site of infection, the patients were generally ill and pyrexial. The group had a very high mortality rate (43%). A positive blood culture was obtained in 11 patients. Biochemical abnormalities noted were those of an increased concentration of conjugated bilirubin in the serum with only a modest increase in alkaline phosphatase and transaminase levels. Serum cholesterol was found to be normal. The mean serum urea level was significantly elevated, as were creatine phosphokinase and lactic dehydrogenase. Most patients exhibited a neutrophil leukocytosis and an elevated sedimentation rate, and the mean hemoglobin level was low. Liver histology was studied in 13 patients. There was evidence of mild bile stasis in 5 and moderate bile stasis in 2. Findings were otherwise nonspecific and were characterized by fatty change and/or inflammatory cells in the portal areas. There was no correlation between degree or duration of juandice and prognosis, although all patients who died remained jaundiced until death. It is suggested that this syndrome is not one of true cholestasis in that all biliary substances were not shown to be elevated in the serum, but that it is rather a selective defect in the excretion of conjugated bilirubin. |
| | |
Authors:
|
D J Miller; D G Keeton; B L Webber; F F Pathol; S J Saunders |
Related Documents
:
|
17543154 - Increased serum levels of nitrotyrosine, a marker for peroxynitrite production, in syst... 7684994 - Ca-125: a marker for persistent gestational trophoblastic disease? 6279034 - Serum angiotensin i-converting enzyme level in patients with cutaneous sarcoidal granul... 8621984 - Bennhold's analbuminemia: a follow-up study of the first two cases (1953-1992). 6647554 - Residual sensorimotor deficits in the adult head-injured patient. a treatment approach. 18594464 - Lumbar adjacent segment degeneration and disease after arthrodesis and total disc arthr... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Gastroenterology Volume: 71 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1976 Jul |
Date Detail:
|
Created Date: 1976-09-01 Completed Date: 1976-09-01 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 94-7 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Bacterial Infections / complications* Female Humans Jaundice / etiology*, microbiology, pathology Male Middle Aged Prognosis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Metabolism of chenodeoxycholate by intestinal mucosa.
Next Document: Test for alcoholic cirrhosis by conversion of [14C]- or [13C]galactose to expired CO2.