| Jaundice due to anti-tuberculous drugs--a dose related phenomenon. | |
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MedLine Citation:
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PMID: 8773037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Data of 429 cases proved to have tuberculosis and on anti-tuberculous short course chemotherapy was analysed to find the incidence of jaundice due to anti-tuberculous drugs. The group included 257 males and 172 females (M : F ratio of 3 : 2), aged 7 to 75 years. 336 patients received short course chemotherapy for a duration of 6 months, while 93 patients were cases of relapse and hence received treatment for 9 months duration. Of these, 7 patients developed drug induced jaundice; 2 each in the age group of 21 to 35 years, and 36 to 50 years while 3 patients were in the age group of 51-65 years. All of these patients developed jaundice within 2 months of treatment and 6 of these 7 patients were receiving drugs in doses which were not adjusted as per the weight of the patient. None of these 6 patients redeveloped jaundice when the drugs were started in doses adjusted accurately as per the weight of the patients, in accordance with IUAT recommendations. One patient (0.21%), who was staredon weight adjusted dosage of anti-TB drugs developed jaundice which was probably due to isoniazed hypersensitivity. |
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Authors:
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L V Mirchandani; J M Joshi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of the Association of Physicians of India Volume: 43 ISSN: 0004-5772 ISO Abbreviation: J Assoc Physicians India Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1996-10-09 Completed Date: 1996-10-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7505585 Medline TA: J Assoc Physicians India Country: INDIA |
Other Details:
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Languages: eng Pagination: 767-9 Citation Subset: IM |
Affiliation:
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Department of Respiratory Medicine, B.Y.L. Nair Hospital, Bombay. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antitubercular Agents / administration & dosage, adverse effects* Body Weight Child Dose-Response Relationship, Drug Drug Therapy, Combination Female Humans Incidence Jaundice / chemically induced*, epidemiology Male Middle Aged Tuberculosis, Pulmonary / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antitubercular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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