Document Detail


Jasmonate biochemical pathway.
MedLine Citation:
PMID:  16478937     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plants possess an interrelated family of potent fatty acid-derived regulators-the jasmonates. These compounds, which play roles in both defense and development, are derived from tri-unsaturated fatty acids [alpha-linolenic acid (18:3) or 7Z,10Z,13Z-hexadecatrienoic acid (16:3)]. The lipoxygenase-catalyzed addition of molecular oxygen to alpha-linolenic acid initiates jasmonate synthesis by providing a 13-hydroperoxide substrate for the formation of an unstable allene oxide that is then subject to enzyme-guided cyclization to produce 12-oxo-phytodienoic acid (OPDA). OPDA has several fates, including esterification into plastid lipids or transformation into the 12-carbon co-regulator jasmonic acid (JA). JA, the best-characterized member of the family, regulates both male and female fertility (depending on the plant species) and is an important mediator of defense gene expression. JA is itself a substrate for further diverse modifications. Genetic dissection of the pathway is revealing how the different jasmonates modulate different physiological processes. Each new family member that is discovered provides another key to understanding the fine control of gene expression in immune responses, in the initiation and maintenance of long-distance signal transfer in response to wounding, in the regulation of fertility, and in the turnover, inactivation, and sequestration of jasmonates, among other processes. The Jasmonate Biochemical Pathway provides an overview of the growing jasmonate family, and new members will be included in future versions of the Connections Map.
Authors:
Robin Liechti; Edward E Farmer
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Publication Detail:
Type:  Journal Article     Date:  2006-02-14
Journal Detail:
Title:  Science's STKE : signal transduction knowledge environment     Volume:  2006     ISSN:  1525-8882     ISO Abbreviation:  Sci. STKE     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-15     Completed Date:  2006-04-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100964423     Medline TA:  Sci STKE     Country:  United States    
Other Details:
Languages:  eng     Pagination:  cm3     Citation Subset:  IM    
Affiliation:
Gene Expression Laboratory, Plant Molecular Biology, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Cyclopentanes / chemistry,  metabolism*
Ethylenes / metabolism
Fertility
Gene Expression Regulation, Plant
Models, Biological*
Molecular Structure
Oxylipins
Plant Diseases
Plant Growth Regulators / chemistry,  physiology*
Plant Physiological Phenomena*
Plant Proteins / physiology
Salicylates / metabolism
Signal Transduction / physiology*
alpha-Linolenic Acid / metabolism
Chemical
Reg. No./Substance:
0/Cyclopentanes; 0/Ethylenes; 0/Oxylipins; 0/Plant Growth Regulators; 0/Plant Proteins; 0/Salicylates; 463-40-1/alpha-Linolenic Acid; 6894-38-8/jasmonic acid; 74-85-1/ethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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