Document Detail

Jarisch-Herxheimer reaction triggered by group B streptococcus intrapartum antibiotic prophylaxis.
MedLine Citation:
PMID:  20664452     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The Jarisch-Herxheimer reaction is an acute systemic event that can occur during the treatment of spirochetal infections. During pregnancy, it can cause signs and symptoms in both the mother and fetus, including fever, tachycardia, uterine contractions, and fetal heart rate pattern changes. CASE: A pregnant woman with limited prenatal care presented at 34 weeks of gestation in preterm labor with possible genital herpes. She received ampicillin for group B Streptococcus prophylaxis. Subsequently, she experienced subjective fever and late fetal heart rate decelerations prompting repeat cesarean delivery. Postpartum, her genital lesions were diagnosed as secondary syphilis, and her newborn had congenital syphilis. CONCLUSION: Beta-lactam antibiotics for group B Streptococcus intrapartum prophylaxis can trigger the Jarisch-Herxhemer reaction in patients with undiagnosed syphilis resulting in unanticipated changes in maternal and fetal well-being.
Martha W F Rac; Laura G Greer; George D Wendel
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  116 Suppl 2     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-28     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  552-6     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Parkland Health and Hospital System, Dallas, Texas, USA.
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MeSH Terms
Ampicillin / adverse effects*
Anti-Bacterial Agents / adverse effects*
Antibiotic Prophylaxis / adverse effects
Fever / etiology
Heart Rate, Fetal
Infant, Newborn
Pregnancy Complications, Infectious / diagnosis*,  drug therapy
Streptococcal Infections / prevention & control*
Streptococcus agalactiae*
Syphilis / diagnosis*,  drug therapy
Syphilis, Congenital / drug therapy,  etiology
Young Adult
Reg. No./Substance:
0/Anti-Bacterial Agents; 69-53-4/Ampicillin

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