| Jarisch-Herxheimer reaction triggered by group B streptococcus intrapartum antibiotic prophylaxis. | |
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MedLine Citation:
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PMID: 20664452 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The Jarisch-Herxheimer reaction is an acute systemic event that can occur during the treatment of spirochetal infections. During pregnancy, it can cause signs and symptoms in both the mother and fetus, including fever, tachycardia, uterine contractions, and fetal heart rate pattern changes. CASE: A pregnant woman with limited prenatal care presented at 34 weeks of gestation in preterm labor with possible genital herpes. She received ampicillin for group B Streptococcus prophylaxis. Subsequently, she experienced subjective fever and late fetal heart rate decelerations prompting repeat cesarean delivery. Postpartum, her genital lesions were diagnosed as secondary syphilis, and her newborn had congenital syphilis. CONCLUSION: Beta-lactam antibiotics for group B Streptococcus intrapartum prophylaxis can trigger the Jarisch-Herxhemer reaction in patients with undiagnosed syphilis resulting in unanticipated changes in maternal and fetal well-being. |
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Authors:
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Martha W F Rac; Laura G Greer; George D Wendel |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 116 Suppl 2 ISSN: 1873-233X ISO Abbreviation: Obstet Gynecol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 552-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Parkland Health and Hospital System, Dallas, Texas, USA. MarthaRac@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Ampicillin
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adverse effects* Anti-Bacterial Agents / adverse effects* Antibiotic Prophylaxis / adverse effects Female Fever / etiology Heart Rate, Fetal Humans Infant, Newborn Pregnancy Pregnancy Complications, Infectious / diagnosis*, drug therapy Streptococcal Infections / prevention & control* Streptococcus agalactiae* Syphilis / diagnosis*, drug therapy Syphilis, Congenital / drug therapy, etiology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 69-53-4/Ampicillin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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