Document Detail

The Jarisch-Herxheimer reaction in leptospirosis: possible pathogenesis and review.
MedLine Citation:
PMID:  2041950     Owner:  NLM     Status:  MEDLINE    
The importance of treating leptospirosis with penicillin is emphasized by two case reports and a review documenting the occurrence of the Jarisch-Herxheimer reaction (JHR) in patients with this bacterial infection. The JHR is significant both as a cause of morbidity and mortality and as an indication of the therapeutic efficacy of penicillin. The possible etiology of the JHR is discussed, and comparisons with the changes occurring in septic shock are made; a study of either condition facilitates the understanding of the other. Tumor necrosis factor is hypothesized to play a key role in both. Current treatment of the JHR consists of general clinical support. Specific measures such as oxpentifylline therapy may play a role in the future.
J S Friedland; D A Warrell
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Reviews of infectious diseases     Volume:  13     ISSN:  0162-0886     ISO Abbreviation:  Rev. Infect. Dis.     Publication Date:    1991 Mar-Apr
Date Detail:
Created Date:  1991-07-08     Completed Date:  1991-07-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7905878     Medline TA:  Rev Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  207-10     Citation Subset:  IM    
Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
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MeSH Terms
Leptospirosis / complications*,  drug therapy
Middle Aged
Penicillins / therapeutic use*
Shock, Septic / etiology*,  physiopathology
Tumor Necrosis Factor-alpha / physiology
Reg. No./Substance:
0/Penicillins; 0/Tumor Necrosis Factor-alpha
Comment In:
Rev Infect Dis. 1991 Nov-Dec;13(6):1245-6   [PMID:  1775860 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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