Document Detail


Jarisch-Herxheimer reaction after penicillin therapy among patients with syphilis in the era of the hiv infection epidemic: incidence and risk factors.
MedLine Citation:
PMID:  20825309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of and risk factors for Jarisch-Herxheimer (JH) reaction were investigated prospectively among 240 human immunodeficiency virus (HIV)-infected and 115 HIV-uninfected patients with syphilis who received penicillin treatment. The overall rate of JH reaction was 31.5% (34.6% in HIV-infected patients and 25.2% in HIV-uninfected patients). In multivariate analysis, risk factors for JH reaction included high rapid plasma reagin (RPR) titers (per log(2) RPR increase, risk ratio [RR], 1.19; 95% confidence interval [CI], 1.04-1.37), early syphilis (RR, 8.59; 95% CI, 4.75-15.56), and prior penicillin treatment (RR, 0.39; 95% CI, 0.20-0.78).
Authors:
Chia-Jui Yang; Nan-Yao Lee; Yu-Hui Lin; Hsin-Chun Lee; Wen-Chien Ko; Chun-Hsing Liao; Cheng-Hsin Wu; Chia-Ying Hsieh; Pei-Ying Wu; Wen-Chun Liu; Ya-Chu Chang; Chien-Ching Hung
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  51     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-22     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  976-9     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Far Eastern Memorial Hospital, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anti-Bacterial Agents / administration & dosage*
Exanthema / chemically induced*,  epidemiology
Female
Fever / chemically induced*,  epidemiology
HIV Infections / complications
Humans
Incidence
Male
Middle Aged
Penicillins / administration & dosage*
Prospective Studies
Reagins / blood
Risk Factors
Syphilis / complications*,  drug therapy*,  pathology
Vasodilation*
Young Adult
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Penicillins; 0/Reagins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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