Document Detail

Jararhagin, a hemorrhagic snake venom metalloproteinase from Bothrops jararaca.
MedLine Citation:
PMID:  22534074     Owner:  NLM     Status:  Publisher    
Jararhagin is a metalloproteinase isolated from Bothrops jararaca snake venom, which has been extensively studied. These studies showed its involvement on most of the systemic and local damaging effects of snakebite envenomings. In this review we comment on the major targets of jararhagin as the vascular endothelium, platelets and coagulation factors and also its action on other cell systems as inflammatory cells and their mediators, cancer and cell signaling. The mechanisms of jararhagin action are discussed together with structural features essential for the expression of its biological activities. The studies reviewed here denote jararhagin as a prototype for studies of snake venom metalloproteinases, bringing new insights into cellular-matrix interactions and adding for the improvement of snakebite treatment.
Ana M Moura-da-Silva; Cristiani Baldo
Related Documents :
12082144 - Prolonged arrest of mammalian cells at the g1/s boundary results in permanent s phase s...
1498364 - Phosphorylation of far1 in response to alpha-factor: a possible requirement for cell-cy...
7174744 - The role of protein metabolism in glucocorticoid-induced prolongation of g1 phase in hu...
3693414 - Messenger rnas coding for enzymes of polyamine biosynthesis are induced during the g0-g...
14980504 - Dynamic association of the mammalian insulator protein ctcf with centrosomes and the mi...
18272544 - Activated neutrophils induce an hmsh2-dependent g2/m checkpoint arrest and replication ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-14
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  -     ISSN:  1879-3150     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Laboratório de Imunopatologia, Instituto Butantan, Av. Vital Brasil 1500, CEP-05503-900 São Paulo, SP, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  First report of (homo)anatoxin-a and dog neurotoxicosis after ingestion of benthic cyanobacteria in ...
Next Document:  Reliability of KRAS mutation testing in metastatic colorectal cancer patients across five laboratori...