| Japanese Encephalitis Virus-Infected Macrophages Induce Neuronal Death. | |
| | |
MedLine Citation:
|
PMID: 21424747 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Inflammation in the central nervous system (CNS) in Japanese encephalitis (JE) is shown to be the result of microglial activation that leads to the release of various proinflammatory mediators. Peripheral macrophages have been reported to infiltrate into the CNS in JE, though their contribution to the inflammatory process is yet to be elucidated. In this study, using an in vitro macrophage model, we have shown that upon JE virus infection, these cells secrete various soluble factors which may significantly add to the existing inflammatory milieu and lead to apoptotic or necrotic death of neurons. However, it is difficult to quantify the extent of involvement of either the microglia or infiltrating macrophages in the inflammatory processes. |
| | |
Authors:
|
Arshed Nazmi; Kallol Dutta; Sulagna Das; Anirban Basu |
Related Documents
:
|
18298497 - Immune-challenged house wren broods differ in the relative strengths of their responses... 21340977 - Hemostasis : components and processes. 712077 - Studies on immunosuppression by cobra venom factor. ii. on responses to dnp-ficoll and ... 19951957 - Cd16/32-specific biotinylated 2.4g2 single-chain fv complexed with avidin-fitc enhances... 17900957 - Involvement of beta 2-integrin in ros-mediated neutrophil apoptosis induced by entamoeb... 21906657 - Chronic inorganic mercury exposure induces sex-specific changes in central tnfα expres... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-22 |
Journal Detail:
|
Title: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Volume: - ISSN: 1557-1904 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101256586 Medline TA: J Neuroimmune Pharmacol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
National Brain Research Centre, Manesar, Haryana, 122050, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bone Structural Components Regulating Sites of Tumor Metastasis.
Next Document: A new phenotype of mitochondrial disease characterized by familial late-onset predominant axial myop...