Document Detail

The Janus effect: two faces of aldosterone.
MedLine Citation:
PMID:  19116642     Owner:  NLM     Status:  MEDLINE    
Inhibition of the nitric oxide pathway by N(omega)-nitro-l-arginine methyl ester (l-NAME) is well known to produce hypertension and proteinuria, but the mechanisms are less straightforward. Prolonged administration of mineralocorticoids mimics the pathological findings produced by l-NAME. Ikeda and colleagues provide a clue to the mechanism by showing that exposure to l-NAME increases plasma aldosterone 50-fold, and that spironolactone markedly attenuates the renal changes. Thus, chronic l-NAME exposure may turn out to be a model of mineralocorticoid excess.
Andrew S Brem
Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  75     ISSN:  1523-1755     ISO Abbreviation:  Kidney Int.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-31     Completed Date:  2009-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  137-9     Citation Subset:  IM    
Division of Kidney Diseases and Hypertension, Rhode Island Hospital, Providence, Rhode Island 02903, USA.
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MeSH Terms
Adrenal Cortex Hormones / pharmacology
Aldosterone / agonists*,  blood,  physiology*
Kidney Diseases / etiology
NG-Nitroarginine Methyl Ester / pharmacology
Sodium / metabolism
Spironolactone / pharmacology
Reg. No./Substance:
0/Adrenal Cortex Hormones; 50903-99-6/NG-Nitroarginine Methyl Ester; 52-01-7/Spironolactone; 52-39-1/Aldosterone; 7440-23-5/Sodium
Comment On:
Kidney Int. 2009 Jan;75(2):147-55   [PMID:  18923385 ]

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