Document Detail


The James Blundell Award Lecture 2006: transfusion and the treatment of haemorrhage: past, present and future.
MedLine Citation:
PMID:  17903138     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the early years of the 19th century, James Blundell reported in the Lancet the first clinical application of blood transfusion for the treatment of haemorrhage. Although these initial experiments may appear to us to have burst upon the medical world, Blundell had in fact done a decade of pre clinical research using animal models to establish principles to be brought to the clinic. His pivotal pre clinical experiments and the insights he gained are described in detail. Today, blood transfusion remains the cornerstone of treatment for serious bleeding - not only to restore oxygen carrying capacity but also to improve haemostasis, arrest and prevent bleeding. However, the indications for the use of blood components to treat bleeding remain ill-defined. In particular, despite the enormous volumes of fresh frozen plasma (FFP) transfused worldwide, the evidence that commonly used coagulation tests are reliable guides to transfusion with FFP is scant. Recent laboratory and clinical studies provide insight into the weaknesses of current coagulation tests as a guide to blood management. In the future, the application of genomics to haemostasis will uncover genetic polymorphisms leading to improved diagnostics and more tailored medical therapeutics. Examples of the emerging use of clinical genomics are presented. Ultimately, the application of widescale genomics testing will refresh our understanding of human physiology and will reassert the importance of the individual in patient care.
Authors:
W H Dzik
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Publication Detail:
Type:  Biography; Historical Article; Lectures    
Journal Detail:
Title:  Transfusion medicine (Oxford, England)     Volume:  17     ISSN:  0958-7578     ISO Abbreviation:  Transfus Med     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-01     Completed Date:  2007-12-06     Revised Date:  2008-07-31    
Medline Journal Info:
Nlm Unique ID:  9301182     Medline TA:  Transfus Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  367-74     Citation Subset:  IM    
Affiliation:
Blood Transfusion Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusettes, USA. sdzik@partners.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Transfusion / history*
Genomics
Hemorrhage / therapy*
Hemostasis / physiology*
History, 19th Century
History, 20th Century
History, 21st Century
Humans
Pharmacogenetics
Plasma
Personal Name Subject
Personal Name Subject:
James Blundell

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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