| Jagged1 and Notch1 help edit M cell patterning in Peyer's patch follicle epithelium. | |
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MedLine Citation:
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PMID: 22504165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mucosal epithelium M cells are dispersed across Peyer's patch follicle associated epithelium (PPFAE) with minimal clustering. Since Notch signaling can influence patterning in epithelia, we examined its influence on PPFAE M cell distribution. Conditional deletion of Notch1 in intestinal epithelium increased PPFAE M cells and also increased M cell clustering, implying a role for Notch in both M cell numbers and lateral inhibition. By contrast, conditional deletion of the ligand Jagged1 also increased M cell clustering, but with a paradoxical decrease in M cell density. In vitro, inhibition of Notch signaling reduced expression of an M cell associated gene CD137, consistent with cis-promoting effects on M cell development. Thus, Jagged1 may have a cis-promoting role in committed M cells, but a trans-inhibitory effect on neighboring cells. In sum, Jagged1-Notch signaling may edit the pattern of M cells across the PPFAE, which may help optimize mucosal immune surveillance. |
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Authors:
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En-Hui Hsieh; David D Lo |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-04-12 |
Journal Detail:
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Title: Developmental and comparative immunology Volume: 37 ISSN: 1879-0089 ISO Abbreviation: Dev. Comp. Immunol. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-06-12 Completed Date: 2012-08-31 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7708205 Medline TA: Dev Comp Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 306-12 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Division of Biomedical Sciences, University of California Riverside, CA 92521, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium-Binding Proteins / metabolism* Goblet Cells / immunology Intercellular Signaling Peptides and Proteins / metabolism* Intestinal Mucosa / cytology*, immunology*, metabolism Membrane Proteins / metabolism* Mice Monitoring, Immunologic Peyer's Patches / cytology*, immunology*, metabolism Receptor, Notch1 / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI063426/AI/NIAID NIH HHS; R01 AI063426/AI/NIAID NIH HHS; R21 AI073689/AI/NIAID NIH HHS; R21 AI073689/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Calcium-Binding Proteins; 0/Intercellular Signaling Peptides and Proteins; 0/Membrane Proteins; 0/Notch1 protein, mouse; 0/Receptor, Notch1; 134324-36-0/Serrate proteins |
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