Document Detail


Jagged1 and Notch1 help edit M cell patterning in Peyer's patch follicle epithelium.
MedLine Citation:
PMID:  22504165     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mucosal epithelium M cells are dispersed across Peyer's patch follicle associated epithelium (PPFAE) with minimal clustering. Since Notch signaling can influence patterning in epithelia, we examined its influence on PPFAE M cell distribution. Conditional deletion of Notch1 in intestinal epithelium increased PPFAE M cells and also increased M cell clustering, implying a role for Notch in both M cell numbers and lateral inhibition. By contrast, conditional deletion of the ligand Jagged1 also increased M cell clustering, but with a paradoxical decrease in M cell density. In vitro, inhibition of Notch signaling reduced expression of an M cell associated gene CD137, consistent with cis-promoting effects on M cell development. Thus, Jagged1 may have a cis-promoting role in committed M cells, but a trans-inhibitory effect on neighboring cells. In sum, Jagged1-Notch signaling may edit the pattern of M cells across the PPFAE, which may help optimize mucosal immune surveillance.
Authors:
En-Hui Hsieh; David D Lo
Related Documents :
6692845 - Interaction of liposomes with kupffer cells in vitro.
22564255 - Stable release of bdnf from the fibroblast cell line nih3t3 grown on silicone elastomer...
4042535 - Magnetic albumin/protein a immunomicrospheres. ii. specificity, reproducibility, and re...
18558485 - Checking graphite and stainless anodes with an experimental model of marine microbial f...
1451835 - Quantification of neutral red pinocytosis by small numbers of adherent cells: comparati...
8620055 - Non-transferrin iron uptake by hela cells cultured in serum-free media with different i...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-04-12
Journal Detail:
Title:  Developmental and comparative immunology     Volume:  37     ISSN:  1879-0089     ISO Abbreviation:  Dev. Comp. Immunol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-12     Completed Date:  2012-08-31     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7708205     Medline TA:  Dev Comp Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  306-12     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Division of Biomedical Sciences, University of California Riverside, CA 92521, United States.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Calcium-Binding Proteins / metabolism*
Goblet Cells / immunology
Intercellular Signaling Peptides and Proteins / metabolism*
Intestinal Mucosa / cytology*,  immunology*,  metabolism
Membrane Proteins / metabolism*
Mice
Monitoring, Immunologic
Peyer's Patches / cytology*,  immunology*,  metabolism
Receptor, Notch1 / metabolism*
Grant Support
ID/Acronym/Agency:
R01 AI063426/AI/NIAID NIH HHS; R01 AI063426/AI/NIAID NIH HHS; R21 AI073689/AI/NIAID NIH HHS; R21 AI073689/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Calcium-Binding Proteins; 0/Intercellular Signaling Peptides and Proteins; 0/Membrane Proteins; 0/Notch1 protein, mouse; 0/Receptor, Notch1; 134324-36-0/Serrate proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A review of complementary mechanisms which protect the developing marsupial pouch young.
Next Document:  A novel acute phase reactant, serum amyloid A-like 1, from Oplegnathus fasciatus: Genomic and molecu...