| Jadomycins Derived from the Assimilation and Incorporation of Norvaline and Norleucine. | |
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MedLine Citation:
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PMID: 22050382 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Streptomyces venezuelae ISP5230 is recognized for the production of chloramphenicol and the jadomycin family of natural products. The jadomycins are angucycline natural products containing a unique oxazolone ring incorporating an amino acid present in the minimal culture media. Substitution of different amino acids results in products of varying biological activity. Analysis of cultures of S. venezuelae ISP5230 incubated with l- and d-norvaline and l- and d-norleucine indicated that only the d-configured amino acids were incorporated into the natural products. Subsequently, jadomycin DNV and jadomycin DNL were isolated and characterized (titers 4 and 9 mg L(-1), respectively). The compounds were evaluated in the National Cancer Institute cell line cancer growth inhibition and cytotoxicity screens, for antimicrobial activity against selected Gram-positive and Gram-negative bacteria, and as DNA-cleavage agents in vitro. |
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Authors:
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Stephanie N Dupuis; Thomas Veinot; Susan M A Monro; Susan E Douglas; Raymond T Syvitski; Kerry B Goralski; Sherri A McFarland; David L Jakeman |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-3 |
Journal Detail:
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Title: Journal of natural products Volume: - ISSN: 1520-6025 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Chemistry, Dalhousie University , Halifax, Nova Scotia, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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