Document Detail


Jack fruit lectin-specific glycoconjugate expression during the progression of cervical intraepithelial neoplasia: a study on exfoliated cells.
MedLine Citation:
PMID:  7924807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The expression of glycoconjugates specific to Jack fruit lectin (JFL) was studied in the exfoliated squamous cells of different grades of intraepithelial and invasive neoplasia of the uterine cervix. It was observed that while normal cells showed almost negative binding, the lectin binding percentage of squamous cells significantly increased with increasing atypia of the epithelium. Correlation analysis between different groups revealed that mild lectin binding in cells had a negative correlation and intense binding had a positive correlation with various stages of tumor progression. These results indicate that the number of cells with aberrant expression of glycoconjugates increases as neoplastic transformation advances. The percentage of labeled and unlabeled cells also shows a continuous transition from low to severe grades of cervical intraepithelial neoplasia and invasive carcinomas. The present study therefore shows that JFL may be used as a probe for further elaboration of detection and grading of precancerous and cancerous lesions of the uterine cervix.
Authors:
K R Pillai; P Remani; S Kannan; A Mathew; K Sujathan; T Vijayakumar; M K Nair
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diagnostic cytopathology     Volume:  10     ISSN:  8755-1039     ISO Abbreviation:  Diagn. Cytopathol.     Publication Date:  1994  
Date Detail:
Created Date:  1994-11-10     Completed Date:  1994-11-10     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8506895     Medline TA:  Diagn Cytopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  342-6     Citation Subset:  IM    
Affiliation:
Division of Cytopathology, Regional Cancer Centre, Thiruvananthapuram, India.
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MeSH Terms
Descriptor/Qualifier:
Cervical Intraepithelial Neoplasia / metabolism*
Female
Glycoconjugates / biosynthesis*
Humans
Lectins*
Plant Lectins*
Uterine Cervical Neoplasms / metabolism*
Chemical
Reg. No./Substance:
0/Glycoconjugates; 0/Lectins; 0/Plant Lectins; 0/jacalin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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