| Jacalin: a new laboratory tool in immunochemistry and cellular immunology. | |
| | |
MedLine Citation:
|
PMID: 2668478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In recent years, a new lectin--jacalin--has raised the interest of immunologists because of its original properties with respect to human immunoglobulins and lymphocytes. Its structure and carbohydrate binding specificity are now well documented, and it can be purified easily from jackfruit seeds by ion exchange or affinity chromatography. The binding and precipitating specificities of jacalin with heavy chains of human immunoglobulins allow its use as a diagnostic (IgA subclass typing) and preparative tool (purification of IgA and IgD, removal of IgA from biologic samples and preparations). Other possible applications of jacalin's binding properties also can be envisaged. In addition, the lectin displays a mitogenic activity specific for human CD4 T-lymphocytes; consequently, the proliferative response induced by jacalin appears to represent a new and interesting assay for a functional study of CD4 cells, with obvious applications in primary and acquired, especially AIDS, immune deficiency states. |
| | |
Authors:
|
P Aucouturier; N Pineau; J C Brugier; E Mihaesco; F Duarte; F Skvaril; J L Preud'homme |
Related Documents
:
|
11303648 - Seasonal changes in above- and belowground carbohydrate concentrations of ponderosa pin... 2850818 - Carbohydrate specificity of the galactose-recognizing receptor of rat peritoneal macrop... 7198118 - The isolation and characterization of a root lectin from soybean (glycine max (l), cult... 1710228 - Macrophage membrane glycoproteins that bind griffonia simplicifolia i-b4: effect on cyt... 10858288 - Conformation of the isolated cepsilon3 domain of ige and its complex with the high-affi... 22348778 - Deciphering the mystery of thalidomide teratogenicity. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Journal of clinical laboratory analysis Volume: 3 ISSN: 0887-8013 ISO Abbreviation: J. Clin. Lab. Anal. Publication Date: 1989 |
Date Detail:
|
Created Date: 1989-09-18 Completed Date: 1989-09-18 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8801384 Medline TA: J Clin Lab Anal Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 244-51 Citation Subset: IM; S |
Affiliation:
|
Laboratory of Immunology and Immunopathology, CNRS URA 1172, University Hospital, Poitiers, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Carbohydrates Immunochemistry Immunoglobulins / isolation & purification Immunologic Techniques Lectins* / immunology, isolation & purification, pharmacology Mitogens Plant Lectins* |
| Chemical | |
Reg. No./Substance:
|
0/Carbohydrates; 0/Immunoglobulins; 0/Lectins; 0/Mitogens; 0/Plant Lectins; 0/jacalin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Changes in lymphocyte subset distribution aid in the differential diagnosis of renal allograft dysfu...
Next Document: Development and applications of sensitive enzyme immunoassay for antibodies: a review.