Document Detail

Jab1 has negative effects on p53-mediated genotoxic stresses.
MedLine Citation:
PMID:  19470245     Owner:  NLM     Status:  MEDLINE    
In this study, we use promoter analysis to show that interaction between Jab1 and p53 induces suppression of p53 activation in U2OS and H1299 cells. Interaction between p53 and Jab1 was further confirmed by immunoprecipitation and immunofluorescent analyses. In particular, Jab1 was able to induce nuclear export of p53 as previously reported. When Jab1 was overexpressed in U2OS cells followed by etoposide or hydrogen peroxide (H(2)O(2)), cell death induced by such stresses was protected against. On the contrary, when the level of Jab1 was suppressed in U2OS cells, cytotoxicity imposed by etoposide and H(2)O(2) was dramatically increased, suggesting a cell protective role for Jab1. These results indicate that Jab1 is a negative regulator of p53 and a plausible oncogene.
Eun-Woo Lee; Sangsik Lee; Jaewhan Song
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BMB reports     Volume:  42     ISSN:  1976-6696     ISO Abbreviation:  BMB Rep     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-27     Completed Date:  2009-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101465334     Medline TA:  BMB Rep     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  299-303     Citation Subset:  IM    
Department of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon 440-746, Korea.
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MeSH Terms
Active Transport, Cell Nucleus / physiology
Antineoplastic Agents, Phytogenic / metabolism
Cell Death / physiology
Cell Line, Tumor
DNA Damage*
Etoposide / metabolism
Hydrogen Peroxide / metabolism
Intracellular Signaling Peptides and Proteins / genetics,  metabolism*
Oxidants / metabolism
Peptide Hydrolases / genetics,  metabolism*
Protein Binding
RNA, Small Interfering / genetics,  metabolism
Tumor Suppressor Protein p53 / genetics,  metabolism*
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Intracellular Signaling Peptides and Proteins; 0/Oxidants; 0/RNA, Small Interfering; 0/Tumor Suppressor Protein p53; 33419-42-0/Etoposide; 7722-84-1/Hydrogen Peroxide; EC 3.4.-/Peptide Hydrolases; EC 3.4.-.-/COPS5 protein, human

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